Unc93b1D34A/D34A mice develop systemic lethal inflammation spontaneously. (A) Survival curves of Unc93b1WT/WT, Unc93b1D34A/D34A, or Unc93b1D34A/D34ATlr7-/- mice (blue, red, or green line, respectively). (B and C) Macroscopic images of spleen (B) and liver (C). (D) Microscopic analyses of liver. Histological samples were stained by Hematoxyline and Eosine (H&E) or silver impregnation. (E) Platelet counts in peripheral blood from indicated genotypes of mice. Bars in the graph indicate averages.