Table 1 Production of IL-6 and IL-8 [median (range) ng/ml] by PBMCs and SFMCs upon TLR ligand stimulation.
Cultured with | IL-6 | IL-8 | ||||
|---|---|---|---|---|---|---|
| Â | Normal PBMC (n = 5) | ERA PBMC (n = 7) | ERA SFMC (n = 3) | Normal PBMC (n = 5) | ERA PBMC (n = 7) | ERA SFMC (n = 3) |
Medium | 4.4 (1.5-5.4) | 7.6 (3-16.6) * | 18 (9.3-24.2) | 10 (4.3-12.6) | 12.6 (8.1-35.7) | 10 (4.3-12.6) |
TNF | 13.6 (9.6-14.8) | 16 (12-35) | 21(18-30) | 30.8 (15.8-36.3) | 34.4 (30.8-46.1) | 31 (15.8-36.3) |
Pam3cys | 15.1 (13.3-19.6) | 44 (26-62) ** | 53 (28-71) | 37.1 (11.4-41.8) | 106 (42.6-147.6) ** | 37.1 (11.4-42) |
PolyI:C | 13.1 (1.3-25.8) | 28 (24-4) * | 46 (45-65) | 33.6 (31.1-56.3) | 126(78-167) * | 34(31.1-56.3) |
Flagellin | 14.1 (6.7-23.5) | 34.9 (15-39.2) * | 52.6 (40-53.8)# | 35.2 (16.1-84.2) | 115 (73-162) ** | 35 (16.1-84.2) |
Zymosan | 14.7 (8.8-36.3) | 34 (28.4-39) * | 48 (39.8-56.1)# | 56 (12.6-89.6) | 106 (103-163) ** | 56 (12.6-90) |