Skip to main content

Table 1 Production of IL-6 and IL-8 [median (range) ng/ml] by PBMCs and SFMCs upon TLR ligand stimulation.

From: Over expression of toll-like receptors in peripheral blood and synovial fluid monocytes of enthesitis related arthritis category of juvenile idiopathic arthritis (JIA-ERA) patients contributes to secretion of inflammatory mediators

Cultured with IL-6 IL-8
  Normal PBMC (n = 5) ERA PBMC (n = 7) ERA SFMC (n = 3) Normal PBMC (n = 5) ERA PBMC (n = 7) ERA SFMC (n = 3)
Medium 4.4 (1.5-5.4) 7.6 (3-16.6) * 18 (9.3-24.2) 10 (4.3-12.6) 12.6 (8.1-35.7) 10 (4.3-12.6)
TNF 13.6 (9.6-14.8) 16 (12-35) 21(18-30) 30.8 (15.8-36.3) 34.4 (30.8-46.1) 31 (15.8-36.3)
Pam3cys 15.1 (13.3-19.6) 44 (26-62) ** 53 (28-71) 37.1 (11.4-41.8) 106 (42.6-147.6) ** 37.1 (11.4-42)
PolyI:C 13.1 (1.3-25.8) 28 (24-4) * 46 (45-65) 33.6 (31.1-56.3) 126(78-167) * 34(31.1-56.3)
Flagellin 14.1 (6.7-23.5) 34.9 (15-39.2) * 52.6 (40-53.8)# 35.2 (16.1-84.2) 115 (73-162) ** 35 (16.1-84.2)
Zymosan 14.7 (8.8-36.3) 34 (28.4-39) * 48 (39.8-56.1)# 56 (12.6-89.6) 106 (103-163) ** 56 (12.6-90)
  1. p < 0.05** 0.01 ERA PBMC versus control PBMC p <#0.05 ERA SFMC versus ERA PBMC.
\