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Table 2 Discriminatory capability of biomarkers

From: Identification and evaluation of novel synovial tissue biomarkers in rheumatoid arthritis by laser scanning cytometry

   Affected area MFI
Biomarker candidate Control vs. cohort AUC 95% Confidence interval Sensit. at 90% specif. AUC 95% Confidence interval Sensit. at 90% specif.
CD4 RA 0.64 0.44 - 0.84 7.35 0.57 0.35 - 0.78 9.79
  RA(+) 0.04 0.04 - 0.04 4.27 0.10 0.08 - 0.11 9.60
  RA(++) 0.68 0.43 - 0.94 19.51 0.63 0.35 - 0.90 12.75
CD11b RA 0.79 0.63 - 0.95 51.82 0.76 0.60 - 0.93 51.76
  RA(+) 0.41 0.14 - 0.68 40.81 0.46 0.10 - 0.82 45.86
  RA(++) 0.95 0.85 - 1.00 85.09 0.88 0.68 - 1.00 71.47
CD29 RA 0.83 0.69 - 0.98 51.53 0.69 0.50 - 0.88 50.22
  RA(+) 0.59 0.12 - 1.00 58.59 0.62 0.00 - 1.00 61.82
  RA(++) 0.82 0.63 - 1.00 38.81 0.49 0.13 - 0.84 26.72
CD38 RA 0.72 0.54 - 0.91 22.23 0.70 0.50 - 0.89 17.68
  RA(+) 0.11 0.10 - 0.11 10.59 0.20 0.16 - 0.23 19.64
  RA(++) 0.86 0.61 - 1.00 69.11 0.70 0.47 - 0.93 5.37
CD64 RA 0.89 0.78 - 1.00 76.31 0.82 0.66 - 0.97 69.72
  RA(+) 0.66 0.00 - 1.00 65.72 0.63 0.00 - 1.00 63.09
  RA(++) 1.00 1.00 - 1.00 100.00 0.95 0.78 - 1.00 88.39
CD90 RA 0.83 0.69 - 0.97 57.97 0.78 0.62 - 0.94 53.55
  RA(+) 0.70 0.00 - 1.00 69.70 0.63 0.00 - 1.00 63.21
  RA(++) 0.78 0.59 - 0.98 10.12 0.72 0.50 - 0.94 6.58
CD271 RA 0.46 0.26 - 0.66 7.43 0.47 0.27 - 0.67 9.97
  RA(+) 0.03 0.03 - 0.03 3.31 0.03 0.03 - 0.03 3.28
  RA(++) 0.58 0.27 - 0.88 15.48 0.70 0.44 - 0.95 18.79
CD304 RA 0.72 0.54 - 0.89 42.98 0.69 0.50 - 0.87 42.23
  RA(+) 0.41 0.10 - 0.73 41.31 0.33 0.12 - 0.55 33.35
  RA(++) 0.82 0.62 - 1.00 45.95 0.94 0.83 - 1.00 84.92
HLA-DR RA 0.87 0.74 - 0.99 65.01 0.86 0.74 - 0.99 69.28
  RA(+) 0.72 0.00 - 1.00 72.09 0.77 0.00 - 1.00 76.79
  RA(++) 0.82 0.59 - 1.00 53.56 0.77 0.49 - 1.00 55.01
  1. Expression of listed surface antigens was analyzed on synovial tissue with LSC. Data were obtained with ROC analysis. Bold, AUC > 0.85.