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Table 3 Discriminatory capability of biomarker panels

From: Identification and evaluation of novel synovial tissue biomarkers in rheumatoid arthritis by laser scanning cytometry

   Affected area MFI  
Biomarker candidate Control vs. cohort AUC 95% Confidence interval Sensit. at 90% specif. AUC 95% Confidence interval Sensit. at 90% specif.  
CD38 and CD11b RA 0.77 0.61 - 0.94 46.82 0.77 0.61 - 0.94 44.95  
  RA(+) 0.69 0.48 - 0.89 28.45 0.70 0.49 - 0.90 29.12  
  RA(++) 0.97 0.87 - 1.00 91.98 0.94 0.83 - 1.00 83.20  
CD304 and CD64 RA 0.84 0.71 - 0.98 66.16 0.79 0.63 - 0.95 65.08  
  RA(+) 0.78 0.59 - 0.96 51.07 0.70 0.48 - 0.92 49.88  
  RA(++) 1.00 1.00 - 1.00 100.00 1.00 1.00 - 1.00 100.00  
CD90 and CD29 RA 0.81 0.67 - 0.96 56.42 0.83 0.68 - 0.97 55.84  
  RA(+) 0.86 0.72 - 1.00 70.98 0.86 0.72 - 1.00 66.31  
  RA(++) 0.67 0.42 - 0.92 9.24 0.75 0.49 - 1.00 35.48  
HLA-DR and CD90 RA 0.87 0.74 - 0.99 65.46 0.87 0.74 - 0.99 66.53  
  RA(+) 0.89 0.75 - 1.00 73.92 0.90 0.77 - 1.00 75.96  
  RA(++) 0.83 0.61 - 1.00 53.85 0.79 0.54 - 1.00 51.55  
HLA-DR and CD29 RA 0.86 0.74 - 0.99 63.02 0.88 0.76 - 1.00 69.08  
  RA(+) 0.88 0.75 - 1.00 69.96 0.93 0.83 - 1.00 81.57  
  RA(++) 0.84 0.66 - 1.00 44.26 0.76 0.49 - 1.00 47.12  
CD29, CD90, and HLA-DR RA 0.90 0.79 - 1.00 70.64 0.90 0.79 - 1.00 72.25  
  RA(+) 0.91 0.79 - 1.00 78.20 0.95 0.86 - 1.00 83.07  
  RA(++) 0.87 0.69 - 1.00 58.44 0.71 0.46 - 0.97 56.13  
  1. Listed panels of potential biomarkers were labeled simultaneously by the respective antibodies on synovial tissue and analyzed with LSC. Data were obtained with ROC analysis. Bold, AUC > 0.85.
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