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Figure 5 | Arthritis Research & Therapy

Figure 5

From: A 4-trifluoromethyl analogue of celecoxib inhibits arthritis by suppressing innate immune cell activation

Figure 5

TFM-C supresses the activation of macrophages. B6 mice recieved 10 μg/g TFM-C, celecoxib or vehicle on Day 0 and Day 2, and on Day 3, splenic macrophages were collected and were stimulated by LPS in vitro in the presence of TFM-C, celecoxib or vehicle. Cytokines were detected by ELISA. IL-1β and IL-6 were measured 24 h after stimulation. TNF-α was measured six hours after stimulation. The data shown are from a single experiment representative of three similar experiments. * P < 0.05 compared with control group, * P < 0.05 compared with celecoxib-treated group.

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