Skip to main content

Advertisement

Springer Nature is making SARS-CoV-2 and COVID-19 research free. View research | View latest news | Sign up for updates

Table 1 Baseline characteristics of participants in the AMIS Study (Number = 4,352)

From: Hyperuricemia and untreated gout are poor prognostic markers among those with a recent acute myocardial infarction

  Aspirin group Placebo group
  Quartile 1 Quartile 2 Quartile 3 Quartile 4 Total Quartile 1 Quartile 2 Quartile 3 Quartile 4 Total
sUA range, mg/dL men 2.5-4.5 4.52-5.37 5.38-6.45 6.47-10.45 2.50-10.45 2.38-4.48 4.5-5.42 5.47-6.48 6.52-11.05 2.38-11.05
women 1.4-5.25 5.27-6.03 6.05-7 7.02-12.52 1.40-12.52 1.83-5.28 5.3-6.03 6.05-6.97 6.98-12.12 1.83-12.12
Number 543 541 541 544 2,169 547 539 551 546 2,183
Mean sUA, mg/dL (SD) 4.55
(0.57)
5.55
(0.34)
6.44
(0.34)
8.05
(0.99)
6.15
(1.43)
4.59
(0.57)
5.61
(0.3)
6.43
(0.32)
7.93
(0.91)
6.14
(1.35)
Demographics
   Age at first MI, years (SD) 52.6
(8.0)
52.5
(8.0)
52.6
(8.3)
52.8
(8.2)
52.6
(8.1)
53.0
(7.6)
52.7
(8.1)
52.5
(8.0)
52.7
(7.9)
52.7
(7.9)
   Age at most recent MI, years (SD) 53.1
(7.8)
53.1
(7.9)
53.1
(8.3)
53.5
(8.0)
53.2
(8.0)
53.5
(7.6)
53.1
(8.0)
52.9
(7.9)
53.4
(7.8)
53.2
(7.8)
   Age at randomization, years (SD) 54.8
(8.0)
54.8
(8.0)
54.8
(8.4)
55.1
(8.1)
54.9
(8.1)
55.2
(7.6)
54.8
(8.1)
54.5
(8.0)
55.0
(7.9)
54.9
(7.88)
   Body mass index, kg/m2 (SD) 24.8
(3.2)
25.6
(3.3)
26.1
(3.2)
27.1
(3.7)
25.9
(3.5)
25.1
(3.1)
25.6
(3.2)
26.4
(3.4)
26.8
(3.8)
26.0
(3.5)
   Men, % 88.8 88.2 88.4 88.6 88.5 89.8 89.4 89.7 89.7 89.6
   African American, % 5.7 4.3 6.7 9 6.4 7.1 5.9 3.1 7.5 5.9
Physical examination data
   Sedentary lifestyle, % 16.7 16.3 17.4 21.3 17.9 16.8 15.6 15.4 20.9 17.2
   Alcohol usea, % 88.4 84.7 82.1 82 84.3 88.1 84.6 85.3 80.6 84.7
   Smokerb, % 40.7 40.1 31.8 29.6 35.5 39.9 37.3 31.2 32.8 35.3
   Heavy smokerc, % 10.1 10.3 12.1 10 10.6 7.2 5.8 15.7 11.4 9.8
   Systolic blood pressure, mmHg (SD) 126.4
(15.6)
126.1
(15.4)
129.0
(16.6)
129.6
(16.5)
127.8
(16.1)
127.5 (17.1) 127.1
(15.1)
128.5
(15.5)
129.5
(16.9)
128.2 (16.2)
   Diastolic blood pressure, mmHg (SD) 78.3
(9.4)
78.9
(8.9)
79.6
(9.2)
81.7
(9.8)
79.6
(9.4)
79.2
(9.3)
78.9
(8.9)
80.3
(9.4)
81.9
(10.0)
80.1
(9.5)
Laboratory data
   Total glucose, mg/100 ml (SD) 148.8
(56.8)
155.4
(57.7)
158.4 (50.1) 171.2
(49.9)
158.6
(54.3)
159.1 (67.5) 156.7
(53.3)
160.1
(50.5)
168.9
(52.2)
161.2
(56.3)
   Total cholesterol, mg/dL (SD) 230.4
(44.7)
235.7
(43.3)
240.4 (43.2) 243.2
(49.0)
237.7
(45.5)
234.0 (43.2) 235.1 (42.4) 240.2
(41.8)
241.2
(42.5)
237.7 (42.5)
   Triglycerides, mg/dL (SD) 160.7 (130.0) 173.3
(101.6)
190.6 (149.1) 228.7 (192.2) 189.9 (159.2) 153.3
(86.2)
162.7 (97.0) 191.5 (116.6) 230.1 (169.3) 185.2 (125.7)
Comorbidities, %
Number of prior MI
   1 88.4 86.7 86.1 84.2 86.4 86.1 88.7 90.0 83.0 86.9
   2 10.1 12.4 12.6 13.6 12.2 11.3 10.4 8.5 14.7 11.2
   ≥ 3 1.5 0.9 1.3 2.2 1.5 2.6 0.9 1.5 2.4 1.8
   History of diabetes 13.4 8.1 9.2 8.8 9.9 17 10.4 7.8 10.1 11.3
   History of renal impairment 4.2 4.6 5.2 6.6 5.2 3.7 4.3 4.9 6.8 4.9
   Gout flaresd 3.1 4.4 4.3 8.3 5.0 3.5 2.2 4.5 7.3 4.4
Medications, %
   Gout medicationsd, e 4.2 4.1 3.1 5.0 4.1 3.3 2.0 4.5 4.8 3.7
   Non-aspirin NSAIDs 1.5 1.7 0.4 1.8 1.3 0.7 0.9 0.9 1.3 1.0
   Anti-diabetic medications 7.9 2.8 3.5 3.3 4.4 8.0 4.8 3.4 5.7 5.5
   Blood pressure medications 5.7 8.3 8.9 18.4 10.3 6.4 7.8 8.5 16.7 9.8
   Lipid-lowering medications 5.3 5.7 4.6 4.6 5.1 4.9 3.9 5.4 3.8 4.5
Follow-up time, years (SD) f 2.9
(0.5)
2.9
(0.5)
2.8
(0.5)
2.8
(0.5)
2.8
(0.5)
2.8
(0.5)
2.8
(0.5)
2.9
(0.5)
2.8
(0.6)
2.8
(0.5)
   Minimum (years) 1.0 0.9 0.9 0.9 0.9 0.90 0.90 0.8 0.9 0.8
   Maximum (years) 3.2 3.2 3.2 3.2 3.2 3.2 3.2 3.2 3.1 3.2
  1. a < 1.5 oz/day; bIncludes cigarettes, pipes, and cigars; c > 45 cigarettes/day; dGout flares and medications determined at baseline; eIncludes probenecid, allopurinol, and colchicine; fFollow up from baseline to last observation. Mean (standard deviation) is provided unless specified otherwise. AMIS, Aspirin Myocardial infarction study; MI, myocardial infarction; NSAID, non-steroidal anti-inflammatory drug; sUA, serum urate; SD, standard deviation.