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Table 4 Genes linked to WNT signaling that are significantly up- or down-regulated

From: Tight regulation of wingless-type signaling in the articular cartilage - subchondral bone biomechanical unit: transcriptomics in Frzb-knockout mice

Symbol Name Function
Up-regulated genes in Frzb-/- mice
WNT target genes
Acta2 actin, alpha 2, smooth muscle, aorta Target gene
Rspo2 R-spondin 2 homolog (Xenopus laevis) Target gene and stimulates WNT/β-catenin pathway
Sox17 SRY-box containing gene 17 Target gene
Tbl1x transducin (beta)-like 1X-linked Target gene and adaptor with the ubiquitin-conjugating/19S proteasome
Wisp2 WNT1 inducible signaling pathway protein 2 Target gene
WNT antagonists
Dkk2 dickkopf homolog 2 (Xenopus laevis) Extracellular WNT antagonist
Dkk3 dickkopf homolog 3 (Xenopus laevis) Extracellular WNT antagonist
Nkd1 naked cuticle 1 homolog (Drosophila) Intracellular antagonist
Nkd2 naked cuticle 2 homolog (Drosophila) Intracellular antagonist
Sfrp1 secreted frizzled-related protein 1 Extracellular WNT antagonist
Sfrp2 secreted frizzled-related protein 2 Extracellular WNT antagonist
Sfrp4 secreted frizzled-related protein 4 Extracellular WNT antagonist
WNT receptor
Fzd1 frizzled homolog 1 (Drosophila) WNT receptor
Fzd2 frizzled homolog 2 (Drosophila) WNT receptor
Fzd8 frizzled homolog 8 (Drosophila) WNT receptor
Intracellular messenger molecules
Nfatc2 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 Intracellular messenger in non-canonical calcium-dependent pathway
Nfatc4 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4 Intracellular messenger in non-canonical calcium-dependent pathway
Prickl2 prickle homolog 2 (Drosophila) Intracellular messenger in non-canonical planar cell polarity pathway
Receptors of the TGFβ superfamily pathway
AcvrI activin A receptor, type I type I receptor for the TGFβ family
AcvrIc activin A receptor, type IC type I receptor for the TGFβ family
BmprIb bone morphogenetic protein receptor, type 1B type I receptor for the TGFβ family
Cell adhesion molecules
Cdh13 cadherin 13 Cell adhesion molecule
Dchs1 dachsous homolog 1 (Drosophila) - protocadherin 16 Cell adhesion molecule
Pcdh9 protocadherin 9 Cell adhesion molecule
Pcdh17 protocadherin 17 Cell adhesion molecule
Pcdh18 protocadherin 18 Cell adhesion molecule
Pcdh19 protocadherin 19 Cell adhesion molecule
Down-regulated genes in Frzb-/- mice
WNT antagonists
Dkk1 dickkopf homolog 1 (Xenopus laevis) Extracellular WNT antagonist
Btrc beta-transducin repeat containing Stimulates β-catenin ubiquitinilation
WNT receptor scaffolds
Arrb1 beta-arrestin 1 scaffold in intracellular WNT receptor complex
Arrb2 Beta-arrestin 2