Symbol | Name | Function |
---|---|---|
Up-regulated genes in Frzb-/- mice | ||
WNT target genes | ||
Acta2 | actin, alpha 2, smooth muscle, aorta | Target gene |
Rspo2 | R-spondin 2 homolog (Xenopus laevis) | Target gene and stimulates WNT/β-catenin pathway |
Sox17 | SRY-box containing gene 17 | Target gene |
Tbl1x | transducin (beta)-like 1X-linked | Target gene and adaptor with the ubiquitin-conjugating/19S proteasome |
Wisp2 | WNT1 inducible signaling pathway protein 2 | Target gene |
WNT antagonists | ||
Dkk2 | dickkopf homolog 2 (Xenopus laevis) | Extracellular WNT antagonist |
Dkk3 | dickkopf homolog 3 (Xenopus laevis) | Extracellular WNT antagonist |
Nkd1 | naked cuticle 1 homolog (Drosophila) | Intracellular antagonist |
Nkd2 | naked cuticle 2 homolog (Drosophila) | Intracellular antagonist |
Sfrp1 | secreted frizzled-related protein 1 | Extracellular WNT antagonist |
Sfrp2 | secreted frizzled-related protein 2 | Extracellular WNT antagonist |
Sfrp4 | secreted frizzled-related protein 4 | Extracellular WNT antagonist |
WNT receptor | ||
Fzd1 | frizzled homolog 1 (Drosophila) | WNT receptor |
Fzd2 | frizzled homolog 2 (Drosophila) | WNT receptor |
Fzd8 | frizzled homolog 8 (Drosophila) | WNT receptor |
Intracellular messenger molecules | ||
Nfatc2 | nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 | Intracellular messenger in non-canonical calcium-dependent pathway |
Nfatc4 | nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4 | Intracellular messenger in non-canonical calcium-dependent pathway |
Prickl2 | prickle homolog 2 (Drosophila) | Intracellular messenger in non-canonical planar cell polarity pathway |
Receptors of the TGFβ superfamily pathway | ||
AcvrI | activin A receptor, type I | type I receptor for the TGFβ family |
AcvrIc | activin A receptor, type IC | type I receptor for the TGFβ family |
BmprIb | bone morphogenetic protein receptor, type 1B | type I receptor for the TGFβ family |
Cell adhesion molecules | ||
Cdh13 | cadherin 13 | Cell adhesion molecule |
Dchs1 | dachsous homolog 1 (Drosophila) - protocadherin 16 | Cell adhesion molecule |
Pcdh9 | protocadherin 9 | Cell adhesion molecule |
Pcdh17 | protocadherin 17 | Cell adhesion molecule |
Pcdh18 | protocadherin 18 | Cell adhesion molecule |
Pcdh19 | protocadherin 19 | Cell adhesion molecule |
Down-regulated genes in Frzb-/- mice | ||
WNT antagonists | ||
Dkk1 | dickkopf homolog 1 (Xenopus laevis) | Extracellular WNT antagonist |
Btrc | beta-transducin repeat containing | Stimulates β-catenin ubiquitinilation |
WNT receptor scaffolds | ||
Arrb1 | beta-arrestin 1 | scaffold in intracellular WNT receptor complex |
Arrb2 | Beta-arrestin 2 |