Skip to main content

Advertisement

Table 5 Genes related to ECM matrix and cell adhesion

From: Tight regulation of wingless-type signaling in the articular cartilage - subchondral bone biomechanical unit: transcriptomics in Frzb-knockout mice

Symbol Name Function
Up-regulated genes in Frzb-/- mice
Collagens
Col3a1 Collagen alpha-1(III) chain Fibril forming collagen - co-distributes with type I collagen
Col4a1 Collagen alpha-1(IV) chain Basal lamina collagen
Col4a2 Collagen alpha-2(IV) chain Basal lamina collagen
Col4a4 Collagen alpha-4(IV) chain Basal lamina collagen
Col4a5 Collagen alpha-5(IV) chain Basal lamina collagen
Col4a6 Collagen alpha-6(IV) chain Basal lamina collagen
Col5a1 Collagen alpha-1(V) chain Fibril forming collagen - co-distributes with type I collagen
Col5a3 Collagen alpha-3(V) chain Fibril forming collagen - co-distributes with type I collagen Type V collagen
Col8a2 Collagen alpha-2(VIII) chain Basal lamina collagen
Col12a1 Collagen alpha-1(XII) chain FACIT collagen
Col14a1 Collagen alpha-1(XIV) chain FACIT collagen
Col15a1 Collagen alpha-1(XVIII) chain Antiangiogenic factor - pericellular matrix
Col16a1 Collagen alpha-1(XVI) chain FACIT-collagen
Col18a1 Collagen alpha-1(XVIII) chain antiangiogenic factor - pericellular matrix
Integrins
Itga8 Integrin alpha-8 light chain RGD-binding integrin
Itgbl1 Integrin beta-like protein 1 Type B like integrin
Sdc2 syndecan 2 Heparan proteoglycan transmembrane protein
Growth factors and receptors
Egfr epidermal growth factor receptor Receptor for epidermal growth factor
Igf1 insulin-like growth factor 1 Growth factor stimulating ECM synthesis
Pdgfra platelet derived growth factor receptor alpha chain Receptor for platelet derived growth factors
Vegfc vascular endothelial growth factor c Pro-angiogenic factor - Flt4 ligand
Lims2 LIM and senescent cell antigen-like-containing domain protein 2 Focal adhesion molecule
Cytoskeleton molecules
Acta2 Actin, aortic smooth muscle  
Parva Alpha-parvin Actin binding protein
Vcl Vinculin Actin binding protein
Extracellular matrix - integrin interacting molecules
Lamb1 laminin B1 subunit 1 Extracellular matrix glycoprotein
Lamg1 laminin, gamma 1 Extracellular matrix glycoprotein
Npnt nephronectin Ligand for integrin alpha 8/b1
Tnn tenascin N Extracellular matrix glycoprotein
Tnxb tenascin XB Extracellular matrix glycoprotein
Thbs2 thrombospondin 2 Extracellular matrix glycoprotein
Thbs4 thrombospondin 4 Extracellular matrix glycoprotein
Down-regulated genes in Frzb-/- mice
Integrins
Itga4 Integrin alpha-4  
Itgal Integrin alpha-L  
Itgam Integrin alpha-M  
Itgb2 Integrin beta-2  
Itgb2l Integrin beta-2-like protein  
Focal adhesion molecule
Lims1 LIM and senescent cell antigen-like-containing domain protein 1 Focal adhesion molecule
Cytoskeleton molecules
Parvb Beta-parvin Actin binding protein
Kinases
Map3k1 Mitogen-activated protein kinase kinase kinase 1 Mitogen activated kinase
Mapk13 Mitogen-activated protein kinase 13 Mitogen activated kinase
Grap2 GRB2-related adaptor protein 2 Adapator protein
Lck Proto-oncogene tyrosine-protein kinase LCK T cell specific kinase
Pik3cd Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta isoform Phosphoinositide 3-kinases
Pik3cg Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform Phosphoinositide 3-kinases