Table 5 Genes related to ECM matrix and cell adhesion
Symbol | Name | Function |
|---|---|---|
Up-regulated genes in Frzb-/- mice | ||
Collagens | ||
Col3a1 | Collagen alpha-1(III) chain | Fibril forming collagen - co-distributes with type I collagen |
Col4a1 | Collagen alpha-1(IV) chain | Basal lamina collagen |
Col4a2 | Collagen alpha-2(IV) chain | Basal lamina collagen |
Col4a4 | Collagen alpha-4(IV) chain | Basal lamina collagen |
Col4a5 | Collagen alpha-5(IV) chain | Basal lamina collagen |
Col4a6 | Collagen alpha-6(IV) chain | Basal lamina collagen |
Col5a1 | Collagen alpha-1(V) chain | Fibril forming collagen - co-distributes with type I collagen |
Col5a3 | Collagen alpha-3(V) chain | Fibril forming collagen - co-distributes with type I collagen Type V collagen |
Col8a2 | Collagen alpha-2(VIII) chain | Basal lamina collagen |
Col12a1 | Collagen alpha-1(XII) chain | FACIT collagen |
Col14a1 | Collagen alpha-1(XIV) chain | FACIT collagen |
Col15a1 | Collagen alpha-1(XVIII) chain | Antiangiogenic factor - pericellular matrix |
Col16a1 | Collagen alpha-1(XVI) chain | FACIT-collagen |
Col18a1 | Collagen alpha-1(XVIII) chain | antiangiogenic factor - pericellular matrix |
Integrins | ||
Itga8 | Integrin alpha-8 light chain | RGD-binding integrin |
Itgbl1 | Integrin beta-like protein 1 | Type B like integrin |
Sdc2 | syndecan 2 | Heparan proteoglycan transmembrane protein |
Growth factors and receptors | ||
Egfr | epidermal growth factor receptor | Receptor for epidermal growth factor |
Igf1 | insulin-like growth factor 1 | Growth factor stimulating ECM synthesis |
Pdgfra | platelet derived growth factor receptor alpha chain | Receptor for platelet derived growth factors |
Vegfc | vascular endothelial growth factor c | Pro-angiogenic factor - Flt4 ligand |
Lims2 | LIM and senescent cell antigen-like-containing domain protein 2 | Focal adhesion molecule |
Cytoskeleton molecules | ||
Acta2 | Actin, aortic smooth muscle | |
Parva | Alpha-parvin | Actin binding protein |
Vcl | Vinculin | Actin binding protein |
Extracellular matrix - integrin interacting molecules | ||
Lamb1 | laminin B1 subunit 1 | Extracellular matrix glycoprotein |
Lamg1 | laminin, gamma 1 | Extracellular matrix glycoprotein |
Npnt | nephronectin | Ligand for integrin alpha 8/b1 |
Tnn | tenascin N | Extracellular matrix glycoprotein |
Tnxb | tenascin XB | Extracellular matrix glycoprotein |
Thbs2 | thrombospondin 2 | Extracellular matrix glycoprotein |
Thbs4 | thrombospondin 4 | Extracellular matrix glycoprotein |
Down-regulated genes in Frzb-/- mice | ||
Integrins | ||
Itga4 | Integrin alpha-4 | |
Itgal | Integrin alpha-L | |
Itgam | Integrin alpha-M | |
Itgb2 | Integrin beta-2 | |
Itgb2l | Integrin beta-2-like protein | |
Focal adhesion molecule | ||
Lims1 | LIM and senescent cell antigen-like-containing domain protein 1 | Focal adhesion molecule |
Cytoskeleton molecules | ||
Parvb | Beta-parvin | Actin binding protein |
Kinases | ||
Map3k1 | Mitogen-activated protein kinase kinase kinase 1 | Mitogen activated kinase |
Mapk13 | Mitogen-activated protein kinase 13 | Mitogen activated kinase |
Grap2 | GRB2-related adaptor protein 2 | Adapator protein |
Lck | Proto-oncogene tyrosine-protein kinase LCK | T cell specific kinase |
Pik3cd | Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta isoform | Phosphoinositide 3-kinases |
Pik3cg | Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | Phosphoinositide 3-kinases |