Table 7 Genes linked to the cell cycle that are significantly down-regulated
Symbol | Name | Function |
|---|---|---|
Cyclins and cyclin kinases | ||
Ccna2 | Cyclin a2 | |
Ccnb1 | Cyclin b1 | |
Ccnb2 | Cyclin b2 | |
Ccnd3 | Cyclin d3 | |
Ccne1 | Cyclin e1 | |
Ccne2 | Cyclin e2 | |
Cdk1 | Cyclin dependent kinase 1 | |
Cdk2 | Cyclin dependent kinase 2 | |
Checkpoint regulators | ||
Bub1 | budding uninhibited by benzimidazoles 1 | Kinase in spindle checkpoint function |
Bub1b | budding uninhibited by benzimidazoles 1b | Kinase in spindle checkpoint function |
Chek1 | CHK1 checkpoint homolog | Checkpoint regulator of cell cycle |
Chek2 | CHK2 checkpoint homolog | Checkpoint regulator of cell cycle |
Mad2l1 | mitotic arrest deficient, homolog-like 1 | Mitotic spindle checkpoint |
Minichromosome complex | ||
Mcm2 | minichromosome maintenance deficient 2 mitotin | Regulator of cell cycle |
Mcm4 | minichromosome maintenance deficient 4 | Regulator of cell cycle |
Mcm5 | minichromosome maintenance deficient 5 | Regulator of cell cycle |
Mcm6 | minichromosome maintenance deficient 6 | Regulator of cell cycle |
Mcm7 | minichromosome maintenance deficient 7 | Regulator of cell cycle |
Transcription factors | ||
E2F2 | E2F transcription factor 2 | Regulator of cell cycle |
Tpdp1 | Transcription factor DP1 | Partner of E2F transcription factors |
Tfdp2 | Transcription factor DP1 | Partner of E2F transcription factors |
Ttk | Ttk protein kinase | Mitosis associated kinase |
Other cell cycle regulators | ||
Cdc6 | cell division cycle 6 homolog | Regulator of cell cycle |
Cdc20 | cell division cycle 20 homolog | Regulator of cell cycle |
Cdc25a | cell division cycle 25a homolog | Regulator of cell cycle |
Cdc25b | cell division cycle 25b homolog | Regulator of cell cycle |
Cdc45 | cell division cycle 45 homolog | Regulator of cell cycle |
Dbf4 | DBF4 homolog (S. cerevisiae) | Activator of S-phase kinase |
Espl1 | extra spindle poles-like 1 | Cleavage of sister chromatids |
Fzr1 | fizzy/cell division cycle 20 related 1 | Activation of the anaphase promoting complex during mitosis |
GADD45A | Growth arrest and DNA damage inducible gene 45a | Regulator of DNA repair and inhibitor of the S phase |
Orc1 | origin recognition complex, subunit 1 | Initiation of DNA replication |
Orc6 | origin recognition complex, subunit 6 | Initiation of DNA replication |
Plk1 | Polo-like kinase 1 | Promoter of mitosis |
Pcna | proliferating cell nuclear antigen | Cofactor of DNA polymerase delta |
Rb1 | Retinoblastoma 1 | Regulator of the cell cycle |
Rbl1 | Retinoblastoma like 1 | Regulator of the cell cycle |