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Table 3 AS patients with normal pulmonary function versus patients with restrictive pattern

From: Restrictive pulmonary function is more prevalent in patients with ankylosing spondylitis than in matched population controls and is associated with impaired spinal mobility: a comparative study

  Normal pulmonary function (n= 105) Restrictive pattern (n= 27) P-value
Age (yr), median (min, max) 46 (30,70) 57 (33,68) 0.015
Males, n (%) 66 (63) 21 (78) 0.218
Disease duration (yr) 22 (7,55) 27 (8,46) 0.054
Lifelong non-smokers, n (%) 53 (51) 15 (56) 0.799
FVC (liters), mean (SD) 4.3 (1.1) 2.8 (0.7) < 0.001
FVC % 103.4 (12.8) 69.4 (6.6) < 0.001
FEV1 (liters) 3.4 (0.9) 2.2 (0.5) < 0.001
FEV1 % 96.6 (12.2) 68.6 (7.9) < 0.001
PEF (liters/minute) 493.2 (119.9) 400.0 (101.3) < 0.001
PEF % 100.0 (16.0) 85.5 (15.8) < 0.001
FEV1/FVC % 77.4 (6.1) 79.4 (8.3) 0.158
ASDAS 2.8 (1.0) 3.1 (0.9) 0.140
BASDAI 4.1 (2.1) 4.3 (2.0) 0.709
BASFI 1.8 (0.8, 8.0) 2.9 (0.9, 10.0) 0.003
BASMI 2.9 (1.6) 5.4 (1.8) < 0.001
Chest expansion (cm) 4.6 (2.1) 2.9 (1.8) < 0.001
Lumbar flexion (cm) 4.3 (1.4) 2.4 (1.6) < 0.001
Lumbar lateral flexion (cm) 14.4 (5.6) 7.6 (5.5) < 0.001
TWD (cm) 11.8 (7.8, 43.5) 18.5 (10.5, 38.0) < 0.001
CRP 3.0 (1.0, 57.0) 7.0 (1.0, 28.0) 0.063
ESR 15.0 (2.0, 83.0) 28.0 (1.0, 90.0) 0.006
VO2peak 41.0 (7.2) 35.9 (8.9) 0.002
Anti-TNF-α-medication, n (%) 21 (20) 9 (33) 0.201
  1. PFT results, clinical and laboratory measures in the AS patients (n = 132).
  2. Mann Whitney U test for comparisons of skewed distributions, Independent Sample T-test for normally distributed data. FEV1%, FVC% and PEF% are adjusted for age, gender and actual height. FEV1/FVC % = absolute FEV1/FVC ratio. The other measurements are not adjusted. Chi-Square test for comparisons of categorical data