Figure 1

Results of the data reduction strategy identifying immune response profiles correlated with radiographic joint damage. Shown are stem-and-leaf schematics summarizing the hierarchy of correlation coefficients for each of the stimulus-cytokine principal component analysis scores. (A) Unadjusted Spearman correlation coefficients. (B) Partial Spearman correlation coefficients, adjusted for age, sex, disease duration, rheumatoid factor status, anti-citrullinated protein antibody status, the Health Assessment Questionnaire (HAQ) disability index, the Disease Activity Score in 28 joints (DAS28), and use of methotrexate, biologic response modifiers, and/or prednisone. The decimal point is one digit to the left of the vertical bar (for example, the bottom value in the left panel is r = 0.31). The highest unadjusted and adjusted correlation coefficients (r = 0.31 and r = 0.39, respectively) correspond to the CMV/EBV first principal component score. CMV, cytomegalovirus; EBV, Epstein Barr virus