From: Takayasu's arteritis is associated with HLA-B*52, but not with HLA-B*51, in Turkey
Characteristics | n | HLA-B*52+ (%) | P | OR (95% CI) | HLA-B*51+ (%) | P |
---|---|---|---|---|---|---|
HC | 210 | 14 (6.7) | 52 (24.8) | |||
Men | 97 | 6 (6.2) | 23 (23.7) | |||
Women | 113 | 8 (7.1) | 29 (25.7) | |||
TAK | 330 | 69 (20.9) | 0.000 | 3.7 (2.02 to 6.77) | 75 (22.7) | 0.64 |
Men | 42 | 7 (16.7) | 0.063 | 12 (28.6) | 0.53 | |
Women | 288 | 62 (21.5) | 0.000 | 3.6 (1.66 to 7.79) | 63 (21.9) | 0.43 |
Age at onset | ||||||
< 40 years | 240 | 58 (24.2) | 0.024 | 0.43 (0.20 to 0.91) | 49 (20.4) | 0.11 |
≤ 40 years | 75 | 9 (12.0) | 22 (29.3) | |||
Angiographic subtypeb | ||||||
Type I | 130 | 17 (13.1) | 0.005 | 0.43 (0.23 to 0.78) | 28 (21.5) | 0.78 |
Type Iia | 21 | 8 (38.1) | 6 (28.6) | |||
Type Iib | 9 | 3 (33.3) | 2 (22.2) | |||
Type III | 13 | 5 (38.5) | 3 (23.1) | |||
Type IV | 15 | 3 (20.0) | 1 (6.7) | |||
Type V | 142 | 34 (23.9) | 35 (24.6) | |||
Surgery (all) | ||||||
Present | 66 | 9 (13.6) | 0.092 | 0.51 (0.24 to 1.09) | 13 (19.7) | 0.62 |
Not present | 246 | 58 (23.6) | 57 (23.2) | |||
Surgery after IS treatment | ||||||
Present | 36 | 7 (19.4) | 1.0 | 9 (25) | 0.67 | |
Not present | 273 | 59 (21.6) | 60 (22.0) | |||
Refractory disease | ||||||
Refractory | 114 | 31 (27.4) | 0.084 | 1.68 (0.97 to 2.93) | 20 (17.5) | 0.12 |
Not refractory | 193 | 35 (18.1) | 49 (25.4) |