Figure 4From: Direct transplantation of mesenchymal stem cells into the knee joints of Hartley strain guinea pigs with spontaneous osteoarthritisImmunohistochemical and immunoblot analyses. Immunohistochemistry, western blotting, and quantification of type II collagen, type I collagen, and matrix metalloproteinase (MMP)-13 expressions at week 5 after injection. (A) Immunohistochemical analysis for type II collagen. Bar = 50 μm. (B) Western blot analysis of type II collagen, type I collagen, and MMP-13 (pooled samples in each group, n = 5). (C) Quantitative analysis of the expressions of type II collagen, type I collagen, and MMP-13 relative to the intensity of β-actin. Data are mean ± standard deviation of five guinea pigs in each group. *P < 0.05. HA, hyaluronic acid; MSC, mesenchymal stem cell.Back to article page