Figure 3

Recognition of citrullinated fibronectin peptides by diseased and healthy control sera. The peptides FN-Arg/Cit_1035,1036 and FN-Arg/Cit₂₃₅₆ were used to study the specificity of the anti-FN antibodies. A. Reactivity of RA sera and control sera to FN-Cit_1035,1036. B. Reactivity of RA sera and control sera to FN-Cit₂₃₅₆. C. Reactivity of RA sera and control sera to FN-Arg_1035,1036. D. Reactivity of RA sera and control sera to FN-Arg₂₃₅₆. RA (n = 75); pSS = primary Sjőgren's syndrome (n = 31); MS = multiple sclerosis (n = 31); SLE = systemic lupus erythematosus (n = 31); T1D = type 1 diabetes (n = 32); TB = tuberculosis (n = 29); NS = normal human sera (n = 32). Broken lines indicate cutoff values (mean + 2*SD of NS data); OD450 = optical density at 450 nm.