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Table 3 Comparison of participants with and without ED

From: Erectile dysfunction is frequent in systemic sclerosis and associated with severe disease: a study of the EULAR Scleroderma Trial and Research group

  No erectile dysfunction (n= 23) Erectile dysfunction (n= 105) Odds ratio (95% confidence interval)
IIEF-5 score 23 (22 to 25) 11 (5 to 16) P < 0.001*
Age (years)a 45 (35.1 to 51.8) 55.7 (47.1 to 62.9) P < 0.001*
SSc duration by Raynaud's phenomenon (years) 7.2 (4.3 to 15.3) 7.0 (3.4 to 11.6) P = 0.44
SSc duration by first non-Raynaud's symptom (years) 6.6 (4.3 to 11.8) 5.6 (2.8 to 9.8) P = 0.41
Topoisomerase I (Scl70)-positive 47.6 45.1 0.98 (0.80 to 1.19)
ACA-positive 5.0 18.8 1.21 (1.02 to 1.44)*
U1RNP-positive 0 5.9 1.25 (1.12 to 1.39)*
RNA polymerase III-positive 0 3.5 1.20 (1.08 to 1.33)*
Diffuse SSc 50 65.9 1.13 (0.92 to 1.40)
Puffy hands 57.1 52.9 0.97 (0.80 to 1.16)
mRSS 7 (2 to 19) 14 (8 to 23) P = 0.05*
mRSS > 20 15.8 26.8 1.13 (0.91 to 1.40)
C-reactive protein elevation 14.3 25.3 1.13 (0.93 to 1.37)
Raynaud's phenomenon 90.5 95.5 1.22 (0.69 to 2.17)
Digital ulcers 47.6 41.9 0.95 (0.79 to 1.16)
Synovitis 19.1 19.5 1.01 (0.80 to 1.27)
Joint contractures 19.1 33.3 1.14 (0.95 to 1.36)
Tendon friction rubs 4.8 10.3 1.13 (0.90 to 1.42)
Muscle weakness 9.5 20.7 1.15 (0.96 to 1.38)
Muscle atrophy 4.8 18.4 1.21 (1.03 to 1.42)*
Creatine kinase elevation 19.1 12.2 0.88 (0.62 to 1.25)
Oesophageal symptoms 57.1 59.1 1.02 (0.84 to 1.23)
Stomach symptoms 19.1 12.5 0.90 (0.65 to 1.23)
Intestinal symptoms 4.8 15.9 1.19 (0.99 to 1.41)
Lung fibrosis on chest X-ray or HRCT 42.9 56.9 1.13 (0.87 to 1.47)
Forced vital capacity (% predicted) 95 (87 to 107) 91 (78 to 192) P = 0.52
Forced vital capacity < 80% 9.5 25.7 1.26 (1.01 to 1.56)*
DLCO (% predicted) 81 (73 to 91) 66 (53 to 82) P = 0.08
DLCO < 80% 42.9 63.6 1.24 (0.95 to 1.61)
PAPsys (mmHg) 23.5 (0 to 28) 29 (22 to 37) P = 0.04*
PAPsys > 40 mmHg 0 24.4 1.32 (1.17 to 1.50)*
Diastolic dysfunction 15.8 17.3 1.02 (0.79 to 1.33)
Pericardial effusion 5.6 4.4 0.95 (0.53 to 1.68)
Left ventricular ejection fraction < 60% 27.8 18.3 0.88 (0.65 to 1.20)
Renal crisis 0 4.6 1.25 (1.14 to 1.38)*
Proteinuria 19.1 6.0 0.68 (0.37 to 1.22)
EULAR SSc activity score 1.0 (0.5 to 2.0) 2.5 (1.0 to 3.5) P = 0.02*
High SSc activity (score ≥ 3) 11.8 43.4 1.38 (1.09 to 1.75)*
Hypocomplementaemia 5.0 6.3 1.05 (0.72 to 1.52)
  1. Data presented as median (interquartile range) or percentage unless indicated otherwise. DLCO, diffusion capacity of the lung for carbon monoxide; HRCT; IIEF-5, International Index of Erectile Function-5; mRSS; modified Rodnan skin score; PAPsys, systolic pulmonary arterial pressure; SSc, systemic sclerosis. aAge presented as mean + standard deviation (minimum to maximum). The star (*) denotes statistical significance