|
IIEF-5 score
|
23 (22 to 25)
|
11 (5 to 16)
|
P < 0.001*
|
|
Age (years)a
|
45 (35.1 to 51.8)
|
55.7 (47.1 to 62.9)
|
P < 0.001*
|
|
SSc duration by Raynaud's phenomenon (years)
|
7.2 (4.3 to 15.3)
|
7.0 (3.4 to 11.6)
|
P = 0.44
|
|
SSc duration by first non-Raynaud's symptom (years)
|
6.6 (4.3 to 11.8)
|
5.6 (2.8 to 9.8)
|
P = 0.41
|
|
Topoisomerase I (Scl70)-positive
|
47.6
|
45.1
|
0.98 (0.80 to 1.19)
|
|
ACA-positive
|
5.0
|
18.8
|
1.21 (1.02 to 1.44)*
|
|
U1RNP-positive
|
0
|
5.9
|
1.25 (1.12 to 1.39)*
|
|
RNA polymerase III-positive
|
0
|
3.5
|
1.20 (1.08 to 1.33)*
|
|
Diffuse SSc
|
50
|
65.9
|
1.13 (0.92 to 1.40)
|
|
Puffy hands
|
57.1
|
52.9
|
0.97 (0.80 to 1.16)
|
|
mRSS
|
7 (2 to 19)
|
14 (8 to 23)
|
P = 0.05*
|
|
mRSS > 20
|
15.8
|
26.8
|
1.13 (0.91 to 1.40)
|
|
C-reactive protein elevation
|
14.3
|
25.3
|
1.13 (0.93 to 1.37)
|
|
Raynaud's phenomenon
|
90.5
|
95.5
|
1.22 (0.69 to 2.17)
|
|
Digital ulcers
|
47.6
|
41.9
|
0.95 (0.79 to 1.16)
|
|
Synovitis
|
19.1
|
19.5
|
1.01 (0.80 to 1.27)
|
|
Joint contractures
|
19.1
|
33.3
|
1.14 (0.95 to 1.36)
|
|
Tendon friction rubs
|
4.8
|
10.3
|
1.13 (0.90 to 1.42)
|
|
Muscle weakness
|
9.5
|
20.7
|
1.15 (0.96 to 1.38)
|
|
Muscle atrophy
|
4.8
|
18.4
|
1.21 (1.03 to 1.42)*
|
|
Creatine kinase elevation
|
19.1
|
12.2
|
0.88 (0.62 to 1.25)
|
|
Oesophageal symptoms
|
57.1
|
59.1
|
1.02 (0.84 to 1.23)
|
|
Stomach symptoms
|
19.1
|
12.5
|
0.90 (0.65 to 1.23)
|
|
Intestinal symptoms
|
4.8
|
15.9
|
1.19 (0.99 to 1.41)
|
|
Lung fibrosis on chest X-ray or HRCT
|
42.9
|
56.9
|
1.13 (0.87 to 1.47)
|
|
Forced vital capacity (% predicted)
|
95 (87 to 107)
|
91 (78 to 192)
|
P = 0.52
|
|
Forced vital capacity < 80%
|
9.5
|
25.7
|
1.26 (1.01 to 1.56)*
|
|
DLCO (% predicted)
|
81 (73 to 91)
|
66 (53 to 82)
|
P = 0.08
|
|
DLCO < 80%
|
42.9
|
63.6
|
1.24 (0.95 to 1.61)
|
|
PAPsys (mmHg)
|
23.5 (0 to 28)
|
29 (22 to 37)
|
P = 0.04*
|
|
PAPsys > 40 mmHg
|
0
|
24.4
|
1.32 (1.17 to 1.50)*
|
|
Diastolic dysfunction
|
15.8
|
17.3
|
1.02 (0.79 to 1.33)
|
|
Pericardial effusion
|
5.6
|
4.4
|
0.95 (0.53 to 1.68)
|
|
Left ventricular ejection fraction < 60%
|
27.8
|
18.3
|
0.88 (0.65 to 1.20)
|
|
Renal crisis
|
0
|
4.6
|
1.25 (1.14 to 1.38)*
|
|
Proteinuria
|
19.1
|
6.0
|
0.68 (0.37 to 1.22)
|
|
EULAR SSc activity score
|
1.0 (0.5 to 2.0)
|
2.5 (1.0 to 3.5)
|
P = 0.02*
|
|
High SSc activity (score ≥ 3)
|
11.8
|
43.4
|
1.38 (1.09 to 1.75)*
|
|
Hypocomplementaemia
|
5.0
|
6.3
|
1.05 (0.72 to 1.52)
|
