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Table 5 Relative risk of developing anti-CCP-positive and anti-CCP-negative rheumatoid arthritis for subjects reporting exposure to cosmetics

From: Usage of skin care products and risk of rheumatoid arthritis: results from the Swedish EIRA study

  Anti-CCP-positive RA Anti-CCP-negative RA
Exposure Number of exposed cases/controlsa RRb 95% CI RRc 95% CI Number of exposed cases/controlsa RRb 95% CI RRc 95% CI
Women           
   A 65/118 1.0 Reference 1.0 Reference 38/118 1.0 Reference 1.0 Reference
   B 110/174 1.1 0.7 to 1.7 1.0 0.7 to 1.6 68/174 1.2 0.7 to 1.9 1.1 0.6 to 1.9
   C 106/230 0.8 0.6 to 1.2 0.8 0.5 to 1.2 68/230 0.9 0.6 to 1.5 0.9 0.5 to 1.5
   D 199/370 0.9 0.6 to 1.3 0.8 0.6 to 1.2 116/370 0.9 0.6 to 1.4 0.9 0.6 to 1.4
   E 130/294 0.7 0.5 to 1.1 0.7 0.4 to 1.0 100/294 1.0 0.6 to 1.6 0.9 0.5 to 1.5
Men           
   A 197/359 1.0 Reference 1.0 Reference 113/359 1.0 Reference 1.0 Reference
   B 27/78 0.6 0.4 to 1.0 0.6 0.3 to 1.0 25/78 1.0 0.6 to 1.6 1.1 0.6 to 1.8
   C 12/27 0.7 0.3 to 1.4 0.7 0.3 to 1.4 10/27 1.1 0.5 to 2.5 1.2 0.6 to 2.8
   D 7/13 1.1 0.4 to 2.9 1.1 0.4 to 3.0 5/13 1.3 0.4 to 3.7 1.2 0.4 to 3.6
   E 4/6 1.3 0.3 to 4.7 0.9 0.2 to 3.8 0/6 n.a. n.a. n.a n.a.
All           
   A 162/477 1.0 Reference 1.0 Reference 151/477 1.0 Reference 1.0 Reference
   B 137/252 0.9 0.6 to 1.2 0.8 0.6 to 1.1 93/252 1.1 0.7 to 1.5 1.0 0.7 to 1.5
   C 118/257 0.8 0.6 to 1.1 0.7 0.5 to 1.1 78/257 1.0 0.6 to 1.4 0.9 0.6 to 1.4
   D 206/383 0.9 0.7 to 1.3 0.9 0.6 to 1.2 121/383 0.9 0.6 to 1.4 0.9 0.6 to 1.4
   E 134/300 0.8 0.6 to 1.1 0.7 0.5 to 1.0 100/300 0.9 0.6 to 1.4 0.8 0.5 to 1.3
  1. Relative risk (RR) together with 95% confidence interval (CI) of developing anti-cyclic citrullinated peptide-positive rheumatoid arthritis (RA) and anti-CCP-negative RA for subjects 18 to 70 years old reporting different amounts of exposure to cosmetics compared with those low exposed (A), by gender. aInformation on anti-CCP status is missing for 12 female and five male cases in comparison with Table 3. bAdjusted for age, living area and gender where appropriate. cAdjusted for age, living area, gender, socio-economic status and smoking where appropriate.