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Figure 2 | Arthritis Research & Therapy

Figure 2

From: Local delivery of AAV2-CTLA4IgG decreases sialadenitis and improves gland function in the C57BL/6.NOD-Aec1Aec2mouse model of Sjögren's syndrome

Figure 2

In vivo expression of CTLA4IgG in salivary glands from C57BL/6.NOD- Aec1Aec2 mice. A sandwich ELISA was developed to detect expression of mouse CTLA4 and human IgG (CTLA4IgG) chimeras in homogenates of submandibular salivary glands (A) and serum (B) (Materials & Methods). Data show the mean ± SEM from each group. Mice cannnulated with AAV2-CTLA4IgG (n = 6, pooled into two samples/group) had significant levels of CTLA4IgG protein in the salivary glands compared with mice that received AAV2-LacZ (n = 7, pooled into two samples/group), (two asterisks, P = 0.0003) and serum (asterisk, P = 0.0102) Unpaired student-t test was used in this analysis.

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Arthritis Research & Therapy

ISSN: 1478-6362

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