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Figure 4 | Arthritis Research & Therapy

Figure 4

From: Hypogalactosylation of serum N-glycans fails to predict clinical response to methotrexate and TNF inhibition in rheumatoid arthritis

Figure 4

Change in ratio of agalactosylated to monogalactosylated N-glycans in serum (sG0/G1) with therapy does not distinguish methotrexate (MTX) and TNF inhibition. Relationship between therapy and the correlation between clinical improvement and changes in sG0/G1 for patients in whom MTX or TNF inhibition was the only new therapeutic agent in the interval between t = 0 and t = 3 months. TNF inhibitor (n = 79) (Autoimmune Biomarkers Collaborative Network and Nested I), Spearman's ρ = 0.34; MTX (n = 19) (Nested I only), Spearman's ρ = 0.16 (P = 0.56 vs TNF inhibitor group).

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