Effect of Dll1 blockade on OVX-induced bone loss in mice. OVX or sham-operated mice were treated with control hamster IgG (Ham), HMD1-5 (D1) or HMJ1-29 (J1). Trabecular and cortical BMD, trabecular and cortical bone area, bone volume per tissue volume (BV/TV), polar moment of inertia in the distal femur, osteoclast number/bone perimeter, and osteoclast surface/bone surface were evaluated four weeks after sham operation or OVX. Shown are the mean value ± SEM of 10 femora from 5 mice per group. *, P < 0.05; **, P < 0.01; ***, P < 0.001.