| OM n = 42 |  | CVM n = 20 |  | N-VM n = 18 |  |
---|---|---|---|---|---|---|
 | P-value | HR (95% CI) | P-value | HR (95% CI) | P-value | HR (95% CI) |
Age univariate | < 0.0001 | 1.1 (1.0-1.1) | < 0.0001 | 1.07 (1.04-1.1) | 0.02 | 1,04 (1.00-1.1) |
Age adjusted | Â | Â | Â | Â | Â | Â |
Traditional risk factors | Â | Â | Â | Â | Â | Â |
Smoking | Â | Â | 0.02 | 3.3 (1.3-8.6) | Â | Â |
Hypertension | 0.02 | 2.2 (1.1-4.5) | Â | Â | 0.04 | 2.8 (1.0-7.9) |
Cholesterol, mmol/l | Â | Â | Â | Â | Â | Â |
Triglycerides, mmol/l†| 0.02 | 1.9 (1.1-3.3) |  |  | 0.04 | 2.5 (1.1-5.7) |
Established arterial disease | < 0.0001 | 4.7 (2.4-9.1) | 0.0006 | 5.4 (2.1-13.6) | 0.0006 | 6.3 (2.3-16.9) |
Lupus manifestations | Â | Â | Â | Â | Â | Â |
Nephritis | Â | Â | 0.03 | 3.0 (1.2-7.9) | Â | Â |
Neurological disorder | Â | Â | 0.04 | 2.9 (1.1-7.3) | Â | Â |
Epilepsy | 0.03 | 2.3 (1.1-4.5) | 0.01 | 3.7 (1.4-9.3) | Â | Â |
SLICC > 1 [25] | <0.0001 | 6.3 (2.2-26.5) | 0.04 | 3.7 (1.0-23.5) | 0.002 | 9.6 (1.9-181.1) |
SLAM > 6 [24] | 0.02 | 2.1 (1.1-4.5) | Â | Â | Â | Â |
Autoantibodies against | Â | Â | Â | Â | Â | Â |
Double-stranded DNA | 0.05 | 1.9 (1.0-3.6) | Â | Â | 0.02 | 3.1 (1.2-8.3) |
Cardiolipin IgG low titer | Â | Â | Â | Â | 0.03 | 2.9 (1.1-8.1) |
Cardiolipin IgG medium titer | 0.006 | 2.7 (1.4-5.3) | 0.04 | 3.2 (1.1-8.5) | 0.02 | 3.6 (1.3-9.6) |
beta2glykoprotein-1 | Â | Â | 0.04 | 2.9 (1.0-7.8) | Â | Â |
Any aPL medium titer ¶ | 0.02 | 2.1 (1.1-3.9) | 0.03 | 2.8 (1.1-7.7) | 0.03 | 2.8 (1.1-7.6) |
Sjogrens syndrome A | 0.01 | 0.4 (0.2-0.8) | Â | Â | Â | Â |
Sjogrens syndrome B | 0.04 | 0.4 (0.1-0.9) |  |  | 0.003 | 5 × 10-7 (0-0.4) |
Medications | Â | Â | Â | Â | Â | Â |
Warfarin | 0.004 | 2.9 (1.4-5.7) | 0.01 | 4.1 (1.4-11.1) | 0.03 | 3.3 (1.1-8.3) |
Hyperlipidemia | Â | Â | 0.03 | 7.8 (1.2-27.9) | Â | Â |
Inflammatory markers | Â | Â | Â | Â | Â | Â |
High sensitivity CRP, mg/l†| 0.01 | 1.3 (1.0-1.7) | 0.02 | 1.5 (1.1-2.1) |  |  |
Fibrinogen, g/l†| 0.0002 | 9.5 (3.0-31) | 0.02 | 10.2 (1.6-70) | 0.0005 | 19.9 (3.8-110) |
α-1 antitrypsin, g/l | 0.002 | 3.1 (1.5-5.8) |  |  | 0.001 | 5.1 (2.0-12.0) |
Serum amyloid A, mg/l†| 0.01 | 1.4 (1.1-1.8) | 0.03 | 1.5 (1.0-2.1) |  |  |
Endothelial markers | Â | Â | Â | Â | Â | Â |
Soluble vascular cell adhesion molecule, ng/l†| 0.0005 | 4.0 (1.8-8.2) | 0.004 | 4.9 (1.7-13.5) |  |  |
Von Willebrand factor, %†| 0.009 | 1.9 (1.2-3.0) |  |  |  |  |
Markers of renal damage | Â | Â | Â | Â | Â | Â |
Cystatin C GFR | < 0.0001 | 0.4 (0.2-0.5) | 0.001 | 0.3 (0.2-0.6) | 0.0002 | 0.3 (0.2-0.5) |
Cystatin C†| < 0.0001 | 4.4 (2.4-7.9) | 0.0009 | 5.3 (2.0-13) | 0.0002 | 5.7 (2.4-12.8) |
Creatinine | 0.003 | 1.1 (1.0-1.1) | 0.02 | 4.1 (1.3-10.2) | 0.003 | 4.3 (1.7-9.2) |
Urea, mmol/l†| 0.01 | 2.1 (1.2-3.2) |  |  | 0.02 | 2.3 (1.1-4.0) |
Pathologic urine | 0.04 | 2.2 (1.0-4.4) | Â | Â | 0.04 | 3.5 (1.1-8.1) |