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Figure 3 | Arthritis Research & Therapy

Figure 3

From: Rat tail static compression model mimics extracellular matrix metabolic imbalances of matrix metalloproteinases, aggrecanases, and tissue inhibitors of metalloproteinases in intervertebral disc degeneration

Figure 3

Immunohistochemical expression profile for matrix metalloproteinase (MMP)-3, tissue inhibitor of metalloproteinases (TIMP)-1, and TIMP-2. (a) Representative immunohistochemical loaded disc nucleus pulposus (NP) and annulus fibrosus (AF) sections for MMP-3, TIMP-1, TIMP-2, and negative control at 0, 7, 28, and 56 days of loading (bars: 50 μm). (b) Percentage of immunopositive cells of MMP-3 at 0, 7, 28, and 56 days in the loaded disc = NP: 44.1, 84.7, 79.0, 63.8, respectively, and AF: 19.5, 62.5, 60.4, 52.2, respectively; TIMP-1 = NP: 41.1, 36.7, 34.2, 9.4, respectively, and AF: 17.2, 20.8, 29.3, 11.9, respectively; TIMP-2 = NP: 47.2, 54.6, 27.6, 9.5, respectively, and AF: 15.8, 26.3, 25.3, 16.2, respectively. *P < 0.05 when compared between loaded and unloaded conditions. P < 0.05 when compared between different time points.

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