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Figure 4 | Arthritis Research & Therapy

Figure 4

From: Rat tail static compression model mimics extracellular matrix metabolic imbalances of matrix metalloproteinases, aggrecanases, and tissue inhibitors of metalloproteinases in intervertebral disc degeneration

Figure 4

Immunohistochemical expression profile for a disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS)-4, ADAMTS-5, and tissue inhibitor of metalloproteinases (TIMP)-3. (a) Representative immunohistochemical loaded disc nucleus pulposus (NP) and annulus fibrosus (AF) sections for ADAMTS-4, ADAMTS-5, TIMP-3, and negative control at 0, 7, 28, and 56 days of loading (bars: 50 μm). (b) Percentage of immunopositive cells of ADAMTS-4 at 0, 7, 28, and 56 days in the loaded disc = NP: 45.4, 44.7, 51.1, 14.9, respectively, and AF: 17.1, 23.0, 52.4, 14.5, respectively; ADAMTS-5 = NP: 40.6, 45.7, 41.5, 8.7, respectively, and AF: 9.9, 24.3, 39.7, 8.8, respectively; TIMP-3 = NP: 40.5, 26.3, 12.1, 10.1, respectively, and AF: 13.0, 7.8, 5.5, 3.5, respectively. *P < 0.05 when compared between loaded and unloaded conditions. P < 0.05 when compared between different time points.

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