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Figure 6 | Arthritis Research & Therapy

Figure 6

From: Rat tail static compression model mimics extracellular matrix metabolic imbalances of matrix metalloproteinases, aggrecanases, and tissue inhibitors of metalloproteinases in intervertebral disc degeneration

Figure 6

Schematic illustration summarizing static compression loading-induced extracellular matrix metabolic imbalances of matrix metalloproteinases (MMPs), aggrecanases belonging to a disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS) family, and tissue inhibitors of metalloproteinases (TIMPs) in the disc nucleus pulposus (NP) and annulus fibrosus (AF). A dominant imbalance of MMP-3/TIMP-1 and TIMP-2 relative to ADAMTS-4 and ADAMTS-5/TIMP-3 is an indication of an advanced stage of intervertebral disc degeneration.

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