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Table 3 Baseline and 3-month and 6-month tocilizumab therapy criteria in 13 patients with axial spondyloarthritis

From: Is IL-6 an appropriate target to treat spondyloarthritis patients refractory to anti-TNF therapy? a multicentre retrospective observational study

  Pt 1 Pt 2 Pt 3 Pt 4 Pt 5 Pt 6 Pt 7 Pt 8 Pt 9 Pt 10 Pt 11 Pt 12 Pt 13
BASDAI, 0 to 100              
   M0 78 90 72 42 77 63 80 48 49 59 48 72 57
   M3 (change from M0; %) +6 -19 +1 -15 +1 -1.6 +3.8 -2 +4 -5 +43 -10 -12
   M6 (change from M0; %) NA NA NA -17 NA NA NA NA -6 -15 +17 NA NA
ASDAS              
   M0 4.87 3.35 3.24 3.37 5 5.36 3.8 2.98 2.68 2.41 2.94 3.2 4.12
   M3 (change from M0; units) -1.6 -0.8 -0.75 -0.04 -1.5 -1.7 -0.3 -0.24 -1.36 -0.43 -0.35 +0.02 -1.96
   M6 (change from M0; units) NA NA NA -1.17 NA NA NA NA -1.02 -0.61 -0.23 NA NA
BASFI, 0 to 100              
   M0 86 95 63 32 72 MD MD 59.5 50 57 59 28 36
   M3 (change from M0; %) -8 -8 +16 +3 +28 MD MD -6 +6 -7 +30 -29 +47
   M6 (change from M0; %) NA NA NA +22 NA MD MD NA 0 -7 -34 NA NA
Pain VAS, 0 to 10              
   M0 9 10 7 4 7 7 8 4 5 6 5 7 4
   M3 (change from M0; units) +0.5 -3 +1 0 0 -0.2 +1 +3 +1 -2 0 -1 0
   M6 (change from M0; units) NA NA NA -1 NA NA NA NA +1 -2 +2 NA NA
CRP (mg/dl)a              
   M0 29 0 2 46 35 96 10 10.4 1 1 1.8 3 35.2
   M3 (absolute value) 0.3 0 0 NA 3 4 1 < 5 NA NA NA 3 1
   M6 (absolute value) NA NA NA 6 NA NA NA NA 0 1 0.6 NA NA
ESR (mm)a              
   M0 71 9 8 47 35 104 21 12 9 8 1 11 15
   M3 (absolute value) 10 2 4 NA 2 2 1 3 NA NA NA 3 1
   M6 (absolute value) NA NA NA 5 NA NA NA NA 4 1 1 NA NA
  1. BASDAI, Bath Ankylosing Spondylitis Disease Activity Index; ASDAS, Assessment of SpondyloArthritis International Society-endorsed disease activity score; BASFI, Bath Ankylosing Spondylitis Functional Index; VAS, visual analogue scale; CRP, C-reactive protein; ESR, erythrocyte sedimentation rate; M0, month 0 (baseline); M3, month 3; M6, month 6; MD, missing data; NA, not available; Pt, Patient. aFor CRP and ESR, the table shows only the values at baseline (M0) and at last follow-up (M3 or M6).