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Table 1 Effects of long-term B-cell depletion on serum concentrations of total immunoglobulin secretion, autoantibodies and protective antibodiesa

From: Induction of long-term B-cell depletion in refractory rheumatoid arthritis patients preferentially affects autoreactive more than protective humoral immunity

  Baseline 6 months 12 months 18 months 24 months
Total IgG (g/L) 13.4 (5.4 to 16.5) 10.5 (5.4 to 15.0)b 10.4 (5.2 to 13.6) 9.35 (5.2 to 13.6) 9.15 (5.1 to 12.2)c
   ACPA-IgG (U/ml) 423 (65.6 to 1116) 349 (47.0 to 647)b 243 (43.9 to 410) 215 (57.2 to 361) 199 (43.6 to 354)c
   Measles-IgG (U/ml) 3.72 (2.43 to 4.71) 3.81 (2.75 to 5.03) 3.84 (2.53 to 5.03) 3.58 (2.63 to 5.04) 3.67 (2.81 to 4.94)
   Mumps-IgG (U/ml) 3.16 (0.65 to 4.67) 3.31 (0.53 to 4.77) 3.31 (0.46 to 4.89) 3.33 (0.64 to 4.78) 3.62 (0.67 to 5.11)
   Rubella-IgG (U/ml) 101 (50.2 to 303) 100 (29.7 to 310) 91.6 (20.5 to 333) 103 (25.6 to 311) 106 (26.9 to 301)
Total IgM (g/L) 1.7 (0.6 to 3.7) 1.2 (0.3 to 2.1)b 1.1 (0.2 to 2.2) 1.0 (0.2 to 1.9) 0.9 (0.2 to 2.0)c
   ACPA-IgM (U/ml) 35.3 (23.4 to 101) 24.4 (16.3 to 72.9)b 21.4 (16.2 to 49.1) 19.8 (14.4 to 37.0) 20.0 (11.8 to 30.8)c
   RF-IgM (U/ml) 76.0 (10.0 to 792) 32 (8.0 to 385)b 16 (5 to 555) 13 (2.0 to 310) 10 (1 to 208)c
Total IgA (g/L) 2.0 (1.2 to 5.5) 1.7 (1.0 to 5.7)b 1.8 (0.8 to 5.5) 1.6 (0.8 to 4.3) 1.55 (0.8 to 4.2)c
   ACPA-IgA (U/ml) 20.7 (3.16 to 90.8) 12.5 (5.22 to 87.4) 9.79 (2.81 to 97.9) 8.49 (3.69 to 60.3) 8.50 (2.63 to 44.4)c
  1. aACPA = anticitrullinated peptide antibody; Ig = immunoglobulin; RF = rheumatoid factor. Data are medians (ranges). bP < 0.05 (baseline versus 6 months). cP < 0.05 (6 months versus 24 months).