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Table 2 Estimated life span of protective and autoreactive humoral immunity during long-term B-cell depletiona

From: Induction of long-term B-cell depletion in refractory rheumatoid arthritis patients preferentially affects autoreactive more than protective humoral immunity

   Individual data analysis
  Pooled data analysis b Life span in years c
  Median life span in years (Spearman's ρ) d Median (range) Spearman's ρ (range) d
Total IgG 38.3 (0.89) 35.5 (10.1 to ∞) 0.75 (0.09 to 0.99)
   ACPA-IgG 9.08 (0.89) 10.1 (5.22 to ∞) 0.83 (0.48 to 1.0)
   Measles-IgG ∞ (0.66) ∞ (15.9 to ∞) 0.48 (0.01 to 0.92)
   Mumps-IgG ∞ (0.90) ∞ (24.0 to ∞) 0.60 (0.04 to 0.84)
   Rubella-IgG 75.5 (0.35) 153 (9.03 to ∞) 0.41 (0.04 to 0.93)
Total IgM 12.3 (0.96) 10.6 (6.0 to 36.7) 0.83 (0.38 to 1.0)
   ACPA-IgM 11.7 (1.0) 14.9 (5.71 to ∞) 0.88 (0.07 to 0.99)
   RF-IgM 4.78 (0.96) 5.27 (4.35 to 7.20) 0.94 (0.68 to 0.99)
Total IgA 33.5 (0.85) 22.8 (8.47 to ∞) 0.77 (0.26 to 0.95)
   ACPA-IgA 9.48 (0.71) 9.33 (6.15 to 48.4) 0.88 (0.16 to 0.98)
  1. aACPA = anticitrullinated peptide antibody; Ig = immunoglobulin; RF = rheumatoid factor. bLife span was estimated using the median data for all patients pooled together as depicted in Figure 3. cLife span was estimated for each individual patient, here summarised in the depicted medians (ranges). dSpearman's ρ data are correlation coefficients of the linear curves used to estimate the life span, which is explained in the Methods section.