Functional role of IL-22 in psoriatic arthritis

Table 1 IL-22 production by activated synovial fluid (SF) and peripheral blood (PB) CD3⁺ T cells.

		IL-22 concentration (pg/ml)
		24 hr. Incubation			48 hr. Incubation
		Unstimulated (Mean ± SEM)	CD3/CD28 Stimulated (Mean ± SEM)	PMA/Ionomycin Stimulated (Mean ± SEM)	Unstimulated (Mean ± SEM)	PHA Stimulated (Mean ± SEM)
PsA ( n = 10)	SF-T cells	3.85 ± 0.51	14.57 ± 0.80*^$	18.92 ± 0.89**^#$	4.21 ± 0.5	95.55 ± 7.81***^#$
	PB-T cells	3.65 ± 0.23	10.44 ± 0.66*	12.83 ± 0.79*	4.28 ± 0.44	48.13 ± 6.38***^$
RA ( n = 10)	SF-T cells	4.22 ± 0.31	14.32 ± 0.96*^$	18.91 ± 1.97**^#$	4.63 ± 0.37	81.63 ± 5.90***^#$
	PB-T cells	4 ± 0.16	10.56 ± 0.48*	11.88 ± 0.18*	4.1 ± 0.26	53.08 ± 4.58***^$
OA ( n = 8)	SF-T cells	4.63 ± 0.57	8.61 ± 0.79	13.59 ± 0.81*	4.79 ± 0.12	39.06 ± 3.92***
	PB-T cells	3.94 ± 0.22	6.88 ± 0.34	11.44 ± 0.78*	4.04 ± 0.18	32.78 ± 2.56***

* p < 0.05, **p < 0.01, compared to 24 hr unstimulated media; ***p < 0.001, compared to 48 hr unstimulated media, Wilcoxon matched pairs signed rank test. ^#p < 0.05, compared to PB-T cells; ^$p < 0.05, ^$$p < 0.01, compared to that of OA, Mann Whitney test.

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