Effects of the rs3825427 genotype in UBAC2 on luciferase activity in cultured HEK 293 cells. pGL3 luciferase reporter recombinant plasmids containing an UBAC2 promoter sequence with the risk allele T or wild-type G allele at SNP rs3825427 were transfected into HEK293 cells. Renilla luciferase plasmid pTK-SV40 was cotransfected with each construct as an internal control for normalization. The mean ± SD is given for each construct from three experiments. Statistical significance was taken when two-tailed P < 0.05 using SPSS17.0 independent sample t test.