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Table 1 Clinical and laboratory characteristics of patients with GPA and healthy controls

From: Increased frequency of CCR4+ and CCR6+ memory T-cells including CCR7+CD45RAmed very early memory cells in granulomatosis with polyangiitis (Wegener's)

  Patients with GPA in remission Patients with active GPA Healthy controls
Number 12 14 20
Age in years, mean (range) 58 (38-83) 55 (27-77) 51 (21-78)
Sex, male/female 10/2 10/4 11/9
BVAS V3.0, mean (range) 0 10 (4-21)  
CRP in mg/L, mean (range) 8 (1-17) 33 (1-86)  
PR3-ANCA, positive/negative 9/3 14/0  
Methotrexate, number 9 5  
Azathioprine, number 1 0  
Leflunomide, number 2 0  
Cyclophosphamide, number 0 5  
Prednisolone, number 12 10  
Prednisolone dosage in mg 6.1 ± 0.8 11.9 ± 1.9a  
No treatment 0 4  
  1. Remission was defined as BVAS V3.0 (Birmingham Vasculitis Activity Index version 3.0) of 0. Disease activity in patients either with first manifestation or relapsing was defined as BVAS V3.0 of at least 1 (15). Prednisolone dosage is expressed as mean ± standard error of the mean. aP < 0.05 by Mann-Whitney U test. CRP, C-reactive protein; GPA, granulomatosis with polyangiitis; PR3-ANCA, anti-neutrophil cytoplasmic autoantibodies targeting proteinase 3.