Skip to main content

Table 2 Percentages of cytokine-producing CCR4+ and/or CCR6+ cell subsets within the total CD4+ T cell population compared with the CCR4-CCR6- cell subset

From: Increased frequency of CCR4+ and CCR6+ memory T-cells including CCR7+CD45RAmed very early memory cells in granulomatosis with polyangiitis (Wegener's)

Granulomatosis with polyangiitis
  CCR4-CCR6- cells CCR4+CCR6- cells CCR4-CCR6+ cells CCR4+CCR6+ cells
Percentage of IFNγ+ cells 11.3 ± 5.1 5.5 ± 2.0 28.2 ± 4.3 4.0 ± 0.5
Percentage of IL-4+ cells 1.0 ± 0.5 5.5 ± 1.5a 0.6 ± 0.3 1.0 ± 0.4
Percentage of IL-17+ cells 0.1 ± 0.0 0.1 ± 0.0 7.8 ± 1.8a 9.5 ± 0.9b
Percentage of IL-22+ cells 0.1 ± 0.0 0.2 ± 0.1 2.4 ± 0.5a 3.4 ± 0.6a
Healthy controls
  CCR4-CCR6- cells CCR4+CCR6- cells CCR4-CCR6+ cells CCR4+CCR6+ cells
Percentage of IFNγ+ cells 21.7 ± 8.4 13.1 ± 2.0 30.7 ± 1.1 6.0 ± 0.5
Percentage of IL-4+ cells 1.0 ± 0.3 5.4 ± 1.0a 1.5 ± 0.4 2.2 ± 0.6
Percentage of IL-17+ cells 0.1 ± 0.0 0.2 ± 0.0 9.1 ± 1.0a 9.7 ± 1.8a
Percentage of IL-22+ cells 0.1 ± 0.0 0.4 ± 0.2 3.3 ± 0.9a 5.0 ± 2.1a
  1. Percentages of positive cells were assessed by flow cytometry. Values are expressed as mean ± standard error of the mean. aP < 0.5, bP < 0.01, Mann-Whitney U test. CCR, CC chemokine receptor; IFNγ, interferon-gamma; IL, interleukin.