Relative contribution of ovariectomy and Staphylococcus aureus infection on bone loss as analyzed with peripheral quantitative computed tomography (pQCT). Trabecular bone mineral density (BMD) (A) and representative pQCT images (B) at day 14 after intravenous bacterial inoculation in sham-operated and ovariectomized S. aureus-infected mice. Samples from uninfected mice were taken at the same time. Horizontal bars show median values. Solid triangles, sham-operated mice; solid circles, ovariectomized mice. Each symbol represents one mouse. *P < 0.05; **P < 0.01; ***P < 0.001; as analyzed by two-way ANOVA with Bonferroni posttests.