Table 1 Autoantibodies differentially expressed between circulation and joint
Expression | Autoantigen | UniProt accession | Gene name | Functional ontology biological process |
|---|---|---|---|---|
Higher in PL (> 45%) | C-terminal binding protein 1 | Q13363 | CTBP1 | Differentiation, host-virus interaction, transcription regulation |
| Â | Guanine nucleotide binding protein (G protein), alpha 13 | Q14344 | GNA13 | Cellular component movement, platelet activation |
| Â | Presenilin associated, rhomboid-like protein | Q9H300 | PARL | - |
| Â | Trans-2,3-enoyl-CoA reductase | Q9NZ01 | GPSN2 | Fatty acid biosynthesis, lipid synthesis |
| Â | Cas-Br-M (murine) ecotropic retroviral transforming sequence b | Q13191 | CBLB | Ubiquitin conjugation pathway |
| Â | Abhydrolase domain containing 16A | O95870 | BAT5 | - |
| Â | Tubulin, gamma complex associated protein 3 | Q96CW5 | TUBGCP3 | Microtubule nucleation at the centrosome |
| Â | Modulator of apoptosis 1 | Q96BY2 | MOAP1 | Apotosis |
| Â | Family with sequence similarity 76, member B | Q5HYJ3 | FAM76B | - |
| Â | Thyroid hormone receptor, alpha | P10827 | THRA | Nuclear hormone receptor, transcriptional regulation |
| Â | Apolipoprotein A-II | P02652 | APOA2 | Host-virus interaction, lipid transport |
| Â | Eyes absent homolog 2 (Drosophila) | O00167 | EYA2 | DNA damage and repair, transcription regulation |
| Â | IL-6 receptor | P08887 | IL6R | Regulation of the immune response, acute-phase reactions and hematopoiesis |
| Â | G protein-coupled receptor 153 | Q6NV75 | GPR153 | - |
| Â | Histone deacetylase 3 | O15379 | HDAC3 | Anti-apoptosis, histone deacetylation, transcriptional regulation |
| Â | Actin related protein M1 | Q9BYD9 | ARPM1 | - |
| Â | Natural killer cell group 7 sequence | Q16617 | NKG7 | - |
| Â | Mitogen-activated protein kinase kinase 7 | O14733 | MAP2K7 | Activation of JUN kinases |
| Â | Ubiquitin-conjugating enzyme E2A (RAD6 homolog) | P49459 | UBE2A | DNA damage and repair, ubiquitin conjugation pathway |
| Â | v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog | P10721 | KIT | - |
| Â | Pleckstrin homology domain containing, family O member 1 | Q53GL0 | PLEKHO1 | Regulation of the actin cytoskeleton |
| Â | Adaptor-related protein complex 1, sigma 1 subunit | P61966 | AP1S1 | Endocytosis, protein transport |
| Â | neuregulin 1 | Q02297 | NRG1 | Induces growth and differentiation of epithelial, glial, neuronal and skeletal muscle cells |
| Â | Peroxisomal biogenesis factor 5 | P50542 | PEX5 | Protein transport |
| Â | Nuclear receptor subfamily 6, group A, member 1 | Q15406 | NR6A1 | Transcriptional regulation, cell proliferation |
| Â | Serine/threonine kinase 10 | O94804 | STK10 | Serine and threonine phosphorylation |
| Â | Eukaryotic translation initiation factor 1 | P41567 | EIF1 | Protein biosynthesis through ribosomal complexes |
| Â | Zinc finger protein 36, C3H type-like 2 | P47974 | ZFP36L2 | Cell proliferation, regulates response to growth factors |
| Â | Cartilage oligomeric matrix protein | P49747 | COMP | Controls apoptosis and cell adhesion within extracellular matrix |
Higher in SF (> 45%) | Actinin, alpha 1 | A1L0V1 | ACTN1 | - |
Similar levels in PL and SF (< 10%) | Protein phosphatase 2, catalytic subunit, beta isozyme | P62714 | PPP2CB | Protein dephosphorylation |
| Â | Peroxisomal biogenesis factor 10 | O60683 | PEX10 | Peroxisome biogenesis |
|  | mitogen-activated protein kinase kinase kinase 7 | O43318 | MAP3K7 | Component of a protein kinase signal transduction cascade; Stimulates NF-κB activation and the p38 mitogen-activated protein kinase pathway |
| Â | 3-Hydroxy-3-methylglutaryl-CoA synthase 1 | Q01581 | HMGCS1 | Cholesterol, steroin and sterol biosynthesis; lipid synthesis |
| Â | TNF receptor-associated protein 1 | Q12931 | TRAP1 | Chaperone that expresses an ATPase activity |
| Â | Troponin C type 1 (slow) | P63316 | TNNC1 | Regulatory protein of striated muscle contraction |