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Table 4 Effects of clinical variables on the TLR levels in lupus patients (categorical variable)

From: Antagonist-mediated down-regulation of toll-like receptors increases the prevalence of human papillomavirus infection in systemic lupus erythematosus

  TLR3 TLR7 TLR8 TLR9
  Yes No Yes No Yes No Yes No
  n   n   n   n   n   n   n   n  
Clinical manifestation                 
   Neuropsychiatric 13 1.3 ± 1.0 33 1.5 ± 1.7 8 3.8 ± 2.8 18 3.9 ± 2.7 13 12 ± 7 33 12 ± 9 13 12 ± 7 33 12 ± 9
   Nephritis 29 1.2 ± 0.7 17 1.8 ± 2.3 17 3.5 ± 2.5 9 4.5 ± 3.0 29 12 ± 9 17 12 ± 9 29 11 ± 8 17 13 ± 9
   Serositis 13 1.3 ± 1.0 33 1.5 ± 1.7 10 3.8 ± 2.3 16 3.9 ± 2.9 13 11 ± 7 33 12 ± 10 13 11 ± 9 33 12 ± 9
   Hematologic 39 1.4 ± 1.6 7 1.4 ± 1.3 22 3.2 ± 2.4 4 5.1 ± 1.7 39 13 ± 9 7 8 ± 4 39 11 ± 8 7 18 ± 10
High-risk HPV infection 11 1.1 ± 0.6 35 1.5 ± 1.7 8 1.9 ± 1.3 18 4.7 ± 2.7 11 10 ± 9 35 13 ± 9 11 8 ± 5 35 13 ± 9
Immunosuppressive therapy ever                 
   Prednisolone                 
   Ever 38 1.2 ± 1.0 8 2.4 ± 3.0 22 3.5 ± 2.5 4 5.6 ± 3.0 38 12 ± 8 8 13 ± 10 38 11 ± 9 8 16 ± 9
   Current 36 1.2 ± 0.9 10 2.2 ± 2.7 22 3.8 ± 2.6 4 4.1 ± 3.2 36 12 ± 8 10 12 ± 10 36 12 ± 9 10 11 ± 6
   Hydroxychloroquine                 
   Ever 27 1.1 ± 0.5 19 1.8 ± 2.2 15 2.9 ± 2.4 11 5.2 ± 2.5 27 11 ± 7 19 13 ± 11 27 9 ± 7 19 15 ± 10
   Current 16 1.4 ± 1.2 30 1.4 ± 1.7 10 3.6 ± 3.1 16 4.0 ± 2.4 16 13 ± 8 30 11 ± 9 16 12 ± 9 30 12 ± 9
   Azathioprine                 
   Ever 25 1.2 ± 0.6 21 1.7 ± 2.1 16 3.7 ± 2.6 10 4.1 ± 2.8 25 12 ± 9 21 11 ± 8 25 12 ± 10 21 12 ± 7
   Current 8 1.0 ± 0.5 38 1.5 ± 1.6 5 3.4 ± 2.7 21 4.0 ± 2.7 8 9.9 ± 5.6 38 12 ± 9 8 13 ± 12 38 11 ± 8
Cyclophosphamide
(oral or IV)
                
   Ever 6 1.1 ± 0.5 40 1.5 ± 1.6 3 4.2 ± 4.2 23 3.8 ± 2.5 6 7 ± 5 40 13 ± 9 6 8 ± 10 40 12 ± 9
   Current 4 2.1 ± 1.4 42 1.3 ± 1.5 2 N.A. 24 N.A. 4 13 ± 16 42 11 ± 8 4 13 ± 9 42 12 ± 9
   Cyclosporin A                 
   Ever 9 1.5 ± 1.2 37 1.4 ± 1.6 5 4.3 ± 4.2 21 3.8 ± 2.5 9 11 ± 7 37 12 ± 9 9 11 ± 12 37 12 ± 8
   Current - - - - - - - - - - - - - - - -
   Mycophenolate mofetil                 
   Ever 8 1.3 ± 0.5 38 1.4 ± 1.6 5 2.9 ± 2.8 21 4.1 ± 2.6 8 15 ± 14 38 11 ± 7 8 11 ± 9 38 12 ± 9
   Current 5 1.1 ± 0.5 41 1.5 ± 1.6 3 2.6 ± 3.4 23 4.0 ± 2.6 5 14 ± 10 41 12 ± 8 5 11 ± 9 41 12 ± 9
  1. HPV, human papillomavirus; SLE, systemic lupus erythematosus; TLR, toll-like receptor; P <0.05