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Table 2 Frequency of ischaemic heart disease and myocardial infarction in rheumatoid arthritis patients stratified by TGFB1 SNP genotypes

From: Interaction between smoking and functional polymorphism in the TGFB1 gene is associated with ischaemic heart disease and myocardial infarction in patients with rheumatoid arthritis: a cross-sectional study

  Ischemic heart disease Myocardial infarction
  Negative Positive Negative Positive
TGFB1-509 (C/T)     
   CC 165 (79.9%) 39 (19.1%) 181 (88.7%) 23 (11.3%)
   CT 139 (76.0%) 44 (24.0%) 155 (84.7%) 28 (15.3%)
   TT 24 (88.9%) 3 (11.1%) 26 (96.3%) 1 (3.7%)
   CC + CT versus TT OR = 1.92, 95% CI 0.61-6.04 OR = 2.70, 95% CI 0.51-14.38
   CT versus CC + TT OR = 1.42, 95% CI 0.89-2.28 OR = 1.55, 95% CI 0.87-2.77
TGFB1+868 (T/C)     
   TT 141 (83.4%) 28 (16.6%) 151 (89.3%) 18 (10.7%)
   TC 137 (72.9%) 51 (27.1%) 155 (82.4%) 33 (17.6%)
   CC 50 (87.7%) 7 (12.3%) 56 (98.2%) 1 (1.8%)
   TT + TC versus CC OR = 1.92, 95% CI 0.85-4.30 OR = 6.32, 95% CI 1.22-32.89a
   TC versus TT + CC OR = 2.02, 95% CI 1.25-3.27b OR = 2.29, 95% CI 1.26-4.16c
TGFB1+913 (G/C)     
   GG 284 (79.8%) 72 (20.2%) 309 (86.8%) 47 (13.2%)
   GC 42 (75.0%) 14 (25.0%) 51 (91.1%) 5 (8.9%)
   CC 2 (100.0%) 0 (0.0%) 2 (100.0%) 0 (0.0%)
   GG versus GC + CC OR = 0.78, 95% CI 0.41-1.49 OR = 1.49, 95% CI 0.59-3.78
  1. 'Negative' and 'positive' values are presented as number (percentage). aP = 0.008, Padj = 0.072; bP = 0.0037, Padj = 0.033; cP = 0.005, Padj = 0.045. Padj are P values that have been adjusted for multiple testing (nine possible models) by using the Bonferroni procedure. CI, confidence interval; OR, odds ratio; SNP, single-nucleotide polymorphism; TGFB1, transforming growth factor-beta-1.