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Table 2 Frequency of ischaemic heart disease and myocardial infarction in rheumatoid arthritis patients stratified by TGFB1 SNP genotypes

From: Interaction between smoking and functional polymorphism in the TGFB1 gene is associated with ischaemic heart disease and myocardial infarction in patients with rheumatoid arthritis: a cross-sectional study

 

Ischemic heart disease

Myocardial infarction

 

Negative

Positive

Negative

Positive

TGFB1-509 (C/T)

    

   CC

165 (79.9%)

39 (19.1%)

181 (88.7%)

23 (11.3%)

   CT

139 (76.0%)

44 (24.0%)

155 (84.7%)

28 (15.3%)

   TT

24 (88.9%)

3 (11.1%)

26 (96.3%)

1 (3.7%)

   CC + CT versus TT

OR = 1.92, 95% CI 0.61-6.04

OR = 2.70, 95% CI 0.51-14.38

   CT versus CC + TT

OR = 1.42, 95% CI 0.89-2.28

OR = 1.55, 95% CI 0.87-2.77

TGFB1+868 (T/C)

    

   TT

141 (83.4%)

28 (16.6%)

151 (89.3%)

18 (10.7%)

   TC

137 (72.9%)

51 (27.1%)

155 (82.4%)

33 (17.6%)

   CC

50 (87.7%)

7 (12.3%)

56 (98.2%)

1 (1.8%)

   TT + TC versus CC

OR = 1.92, 95% CI 0.85-4.30

OR = 6.32, 95% CI 1.22-32.89a

   TC versus TT + CC

OR = 2.02, 95% CI 1.25-3.27b

OR = 2.29, 95% CI 1.26-4.16c

TGFB1+913 (G/C)

    

   GG

284 (79.8%)

72 (20.2%)

309 (86.8%)

47 (13.2%)

   GC

42 (75.0%)

14 (25.0%)

51 (91.1%)

5 (8.9%)

   CC

2 (100.0%)

0 (0.0%)

2 (100.0%)

0 (0.0%)

   GG versus GC + CC

OR = 0.78, 95% CI 0.41-1.49

OR = 1.49, 95% CI 0.59-3.78

  1. 'Negative' and 'positive' values are presented as number (percentage). aP = 0.008, Padj = 0.072; bP = 0.0037, Padj = 0.033; cP = 0.005, Padj = 0.045. Padj are P values that have been adjusted for multiple testing (nine possible models) by using the Bonferroni procedure. CI, confidence interval; OR, odds ratio; SNP, single-nucleotide polymorphism; TGFB1, transforming growth factor-beta-1.
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Arthritis Research & Therapy

ISSN: 1478-6362

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