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Table 4 Association of TGFB1 heterozygous genotypes with ischaemic heart disease and myocardial infarction in rheumatoid arthritis patients stratified by ever smoking

From: Interaction between smoking and functional polymorphism in the TGFB1 gene is associated with ischaemic heart disease and myocardial infarction in patients with rheumatoid arthritis: a cross-sectional study

Ischemic heart disease Myocardial infarction
  Negative Positive OR (95% CI) Negative Positive OR (95% CI)
Smoke/-509 CT       
   -/- 65 (89.0%) 8 (11.0%) 1.0 (referent) 70 (95.9%) 3 (4.1%) 1.0 (referent)
   -/+ 58 (89.2%) 7 (10.8%) 0.99 (0.35-2.80) 61 (93.8%) 4 (6.2%) 1.47 (0.35-6.21)
   +/- 124 (78.5%) 34 (21.5%) 2.14 (0.95-4.79) 137 (86.7%) 21 (13.3%) 3.15 (0.98-10.10)
   +/+ 81 (68.6%) 37 (31.4%) 3.55 (1.57-7.99)
AP: 0.41 (-0.03-0.84)
94 (79.7%) 24 (20.3%) 5.22 (1.63-16.69)
AP: 0.31 (-0.22-0.84)
Smoke/+868 TC       
   -/- 68 (88.3%) 9 (11.7%) 1.0 (referent) 74 (96.1%) 3 (3.9%) 1.0 (referent)
   -/+ 55 (90.2%) 6 (9.8%) 0.84 (0.29-2.43) 57 (93.4%) 4 (6.6%) 1.67 (0.40-7.02)
   +/- 123 (82.6%) 26 (17.4%) 1.55 (0.70-3.44) 133 (89.3%) 16 (10.7%) 2.63 (0.80-8.63)
   +/+ 82 (64.6%) 45 (35.4%) 3.98 (1.84-8.58)
AP: 0.66 (0.34-0.97)
98 (77.2%) 29 (22.8%) 6.37 (2.02-20.10)
AP: 0.49 (0.08-0.91)
  1. 'Negative' and 'positive' values are presented as number (percentage). AP, the attributable proportion due to interaction; CI, confidence interval; OR, odds ratio; TGFB1, transforming growth factor-beta-1.