A multicenter study confirms CD226gene association with systemic sclerosis-related pulmonary fibrosis

Table 2 Association of CD226 haplotype block in the Fib+ subset of systemic sclerosis patients.

rs763361	rs34794968	rs727088	Subgroup	MAF (%)	P _MH	P _Bonf	OR [CI 95%]	P _BD
			Fib+	0.40
T	A	G	CTRL	0.41	0.59	NS	0.97 [0.86-1.08]	0.45
			Fib-	0.41	0.76	NS	0.98 [0.86-1.11]	0.77
			Fib+	0.10
T	C	G	CTRL	0.08	1.59E-02	3.18E-02	1.27 [1.05-1.54]	0.48
			Fib-	0.08	0.069	NS	1.24 [0.99-1.56]	0.51
			Fib+	0.50
C	C	A	CTRL	0.51	0.44	NS	0.96 [0.86-1.07]	0.71
			Fib-	0.51	0.50	NS	0.95 [0.84-1.09]	0.44

For the haplotype-specific analyses, the odds ratio (OR) with 95% confidence interval (95% CI) was determined for each allele variant in the haplotype tested against all of the others pooled together using the Mantel-Haenszel test under fixed effects model, considering no single reference haplotype. CTRL, healthy controls; Fib-, lung fibrosis negative SSc patients; Fib+, lung fibrosis positive SSc patients; MAF, minor allele frequency; P_Bonf, corrected P-value using Bonferroni multiple test correction.

ISSN: 1478-6362