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Table 1 Characteristics of rheumatoid arthritis cases and controls in the MyEIRA study

From: Smoking interacts with HLA-DRB1 shared epitope in the development of anti-citrullinated protein antibody-positive rheumatoid arthritis: results from the Malaysian Epidemiological Investigation of Rheumatoid Arthritis (MyEIRA)

 

All

Men

Women

 

Cases n = 1,056

Controls n = 1,416

Cases n = 151

Controls n = 211

Cases n = 905

Controls n = 1,205

Age, mean (SD) years

47.7 (11.5)

47.1 (11.4)

50.1 (11.9)

49.8 (11.9)

47.3 (11.4)

46.7 (11.3)

Smoking status

      

Never-smoker, n (%)

927 (88)

1,260 (89)

61 (40)

101 (48)

866 (96)

1159 (96.2)

Ever-smoker, n (%)

79 (7)

65 (5)

70 (46)

60 (28)

9 (1)

5 (0.4)

Information missing on smoking, n (%)

50 (5)

91 (6)

20 (14)

50 (24)

30 (3)

41 (3.4)

Ethnic group

      

Malay

441 (42)

893 (63)

66 (44)

126 (60)

375 (41)

767 (64)

Chinese

217 (20)

183 (13)

36 (24)

31 (15)

181 (20)

152 (13)

Indian

323 (31)

253 (18)

37 (25)

43 (20)

286 (32)

210 (17)

Others

75 (7)

87 (6)

12 (8)

11 (5)

63 (7)

76 (6)

ACPA status

      

ACPA-positive RA, n (%)

680 (64)

32 (2)

104 (69)

5 (2)

576 (64)

27 (2)

ACPA-negative RA, n (%)

376 (36)

1,383 (98)

47 (31)

206 (98)

329 (36)

1,177 (98)

Presence of SE alleles

      

None SE alleles, n (%)

629 (60)

1,183 (84)

83 (55)

181 (86)

546 (60)

1,002 (83)

Any SE alleles, n (%)

425 (40)

233 (16)

68 (45)

30 (14)

357 (39)

203 (17)

  1. ACPA, anti-citrullinated peptide antibody; DNA, deoxyribonucleic acid; MyEIRA, Malaysian Epidemiological Investigation of rheumatoid arthritis; RA, rheumatoid arthritis; SD, standard deviation; SE, shared epitope. The "any SE alleles" group was defined by the presence of either one or two HLA-DRB1*01:01, *01:02, *01:07, *04:01, *04:04, *04:05, *04:08, *04:10, *10:01, and/or *10:03 SE alleles.