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Table 1 Comparison of statin effects on murine collagen-induced arthritis

From: Statins accelerate the onset of collagen type II-induced arthritis in mice

Study Statin Dose (mg/kg) Exposure route Timing (days) Effect on arthritis
Present study A 10 Oral -28 to 20 ΔET50 -7 days
Present study A 10 Oral 22 to 42 ΔET50 -9 days
Present study P 40 Oral -28 to 20 ΔET50 -5 days
Present study P 40 Oral 22 to 42 ΔET50 -7 days
Ho and colleagues [13] A 10 Oral 2 to 49 Suppression
Yamagata and colleagues [14] P 100 Intraperitoneal 0 to 35 Suppression
Leung and colleagues [15] S 40 Intraperitoneal 21 to 40 Suppression
Leung and colleagues [15] S 20 Intraperitoneal 21 to 40 No effect
Leung and colleagues [15] S 10 Intraperitoneal 21 to 40 No effect
Palmer and colleagues [16] A 100 Oral 0 to 48 No effect
Palmer and colleagues [16] A 1 Oral 0 to 48 No effect
Palmer and colleagues [16] R 2 Subcutaneous 0 to 48 No effect
Palmer and colleagues [16] R 0.2 Subcutaneous 0 to 48 No effect
Palmer and colleagues [16] R 40 Intraperitoneal 21 to 35 No effect
Palmer and colleagues [16] S 40 Intraperitoneal 21 to 35 Suppression
Palmer and colleagues [16] S 40 Oral 21 to 35 No effect
  1. A, atorvastatin; P, pravastatin; S, simvastatin; R, rosuvastatin; ΔET50, number of days between the time when 50% of the animals developed arthritis (ET50 value) for the statin-treated animals and the ET50 value for the control animals.