Table 1 Comparison of statin effects on murine collagen-induced arthritis
From: Statins accelerate the onset of collagen type II-induced arthritis in mice
Study | Statin | Dose (mg/kg) | Exposure route | Timing (days) | Effect on arthritis |
|---|---|---|---|---|---|
Present study | A | 10 | Oral | -28 to 20 | ΔET50 -7 days |
Present study | A | 10 | Oral | 22 to 42 | ΔET50 -9 days |
Present study | P | 40 | Oral | -28 to 20 | ΔET50 -5 days |
Present study | P | 40 | Oral | 22 to 42 | ΔET50 -7 days |
Ho and colleagues [13] | A | 10 | Oral | 2 to 49 | Suppression |
Yamagata and colleagues [14] | P | 100 | Intraperitoneal | 0 to 35 | Suppression |
Leung and colleagues [15] | S | 40 | Intraperitoneal | 21 to 40 | Suppression |
Leung and colleagues [15] | S | 20 | Intraperitoneal | 21 to 40 | No effect |
Leung and colleagues [15] | S | 10 | Intraperitoneal | 21 to 40 | No effect |
Palmer and colleagues [16] | A | 100 | Oral | 0 to 48 | No effect |
Palmer and colleagues [16] | A | 1 | Oral | 0 to 48 | No effect |
Palmer and colleagues [16] | R | 2 | Subcutaneous | 0 to 48 | No effect |
Palmer and colleagues [16] | R | 0.2 | Subcutaneous | 0 to 48 | No effect |
Palmer and colleagues [16] | R | 40 | Intraperitoneal | 21 to 35 | No effect |
Palmer and colleagues [16] | S | 40 | Intraperitoneal | 21 to 35 | Suppression |
Palmer and colleagues [16] | S | 40 | Oral | 21 to 35 | No effect |