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Table 1 Association analysis in New Zealand case-control sample sets

From: The renal urate transporter SLC17A1 locus: confirmation of association with gout

SNP a

Cases

MAF

Controls

MAF

P unadjusted

P adjusted b

OR (95% CI)

HWE case

HWE control

rs1165196

TT

CT

CC

C

TT

CT

CC

C

     

Caucasian

167 (0.400)

201 (0.482)

49 (0.118)

0.359

389 (0.318)

590 (0.482)

246 (0.200)

0.442

1.0 × 10-4

5.5 × 10-5

0.71 (0.60 to 0.83)

0.33

0.41

   EP/N

130 (0.570)

86 (0.377)

12 (0.053)

0.241

98 (0.516)

77 (0.405)

15 (0.079)

0.282

0.19

0.26

0.81 (0.60 to 1.11)

0.65

0.98

   EP/Z

16 (0.364)

22 (0.500)

6 (0.136)

0.386

53 (0.358)

64 (0.432)

31 (0.209)

0.426

0.51

0.88

0.85 (0.52 to 1.38)

0.72

0.16

   WP

138 (0.556)

99 (0.399)

11 (0.044)

0.244

69 (0.496)

54 (0.388)

16 (0.115)

0.309

0.05

0.06

0.72 (0.52 to 1.00)

0.20

0.28

   EP/WP

10 (0.667)

5 (0.333)

0 (0.000)

0.167

6 (0.316)

10 (0.526)

3 (0.158)

0.421

0.02

0.07

0.28 (0.09 to 0.87)

0.33

0.73

Combinedc

        

5.7 × 10-7

 

0.72 (0.64 to 0.82)

  

rs1183201 d

TT

TA

AA

A

TT

TA

AA

A

     

Caucasian

158 (0.384)

205 (0.499)

48 (0.117)

0.366

356 (0.291)

608 (0.496)

261 (0.213)

0.461

2.0 × 10-6

3.0 × 10-6

0.67 (0.57 to 0.79)

0.13

0.89

   EP/N

130 (0.570)

86 (0.377)

12 (0.053)

0.241

96 (0.505)

78 (0.411)

16 (0.084)

0.289

0.11

0.14

0.78 (0.57 to 1.06)

0.65

0.98

   EP/Z

15 (0.349)

21 (0.488)

7 (0.163)

0.407

52 (0.349)

61 (0.409)

36 (0.242)

0.446

0.49

0.95

0.85 (0.52 to 1.39)

0.94

0.04

   WP

132 (0.543)

101 (0.416)

10 (0.041)

0.249

68 (0.479)

57 (0.401)

17 (0.120)

0.320

0.03

0.03

0.70 (0.51 to 0.97)

0.08

0.35

   EP/WP

9 (0.600)

6 (0.400)

0 (0.000)

0.200

7 (0.350)

10 (0.500)

3 (0.150)

0.400

0.07

0.11

0.38 (0.13 to 1.12)

0.25

0.99

Combinedc

        

3.0 × 10-8

 

0.70 (0.62 to 0.79)

  

rs9358890

AA

AG

GG

G

AA

AG

GG

G

     

Caucasian

366 (0.884)

47 (0.114)

1 (0.002)

0.059

1114 (0.912)

104 (0.085)

4 (0.003)

0.046

0.12

0.17

1.31 (0.93 to 1.85)

0.69

0.35

   EP/N

97 (0.418)

99 (0.427)

36 (0.155)

0.369

80 (0.419)

78 (0.408)

33 (0.173)

0.377

0.80

0.71

0.96 (0.73 to 1.28)

0.21

0.07

   EP/Z

34 (0.753)

11 (0.244)

0 (0.000)

0.122

129 (0.827)

26 (0.167)

1 (0.006)

0.090

0.44

0.42

1.41 (0.67 to 2.96)

0.35

0.80

   WP

110 (0.440)

101 (0.404)

39 (0.156)

0.358

73 (0.507)

61 (0.424)

10 (0.069)

0.281

0.03

0.06

1.43 (1.04 to 1.95)

0.06

0.57

   EP/WP

8 (0.533)

7 (0.467)

0 (0.000)

0.233

12 (0.571)

7 (0.333)

2 (0.095)

0.262

0.78

0.87

0.86 (0.29 to 2.55)

0.24

0.53

Combinedc

        

0.05

 

1.19 (1.00 to 1.41)

  

rs3799344

CC

CT

TT

T

CC

CT

TT

T

     

Caucasian

165 (0.404)

193 (0.473)

50 (0.123)

0.359

379 (0.309)

592 (0.483)

255 (0.207)

0.450

5.9 × 10-6

2.8 × 10-5

0.69 (0.58 to 0.81)

0.58

0.38

   EP/N

128 (0.561)

88 (0.386)

12 (0.053)

0.246

97 (0.524)

73 (0.395)

15 (0.081)

0.278

0.46

0.37

0.84 (0.62 to 1.15)

0.53

0.80

   EP/Z

17 (0.378)

22 (0.489)

6 (0.133)

0.378

53 (0.353)

64 (0.427)

33 (0.220)

0.433

0.35

0.72

0.79 (0.49 to 1.29)

0.79

0.49

   WP

136 (0.551)

98 (0.397)

13 (0.053)

0.251

64 (0.457)

59 (0.421)

17 (0.121)

0.332

0.02

0.02

0.67 (0.49 to 0.93)

0.39

0.55

   EP/WP

10 (0.667)

5 (0.333)

0 (0.000)

0.167

7 (0.350)

10 (0.500)

3 (0.150)

0.400

0.04

0.08

0.30 (0.10 to 0.95)

0.44

0.85

Combinedc

        

7.4 × 10-8

 

0.71 (0.62 to 0.80)

  

rs12664474

AA

AG

GG

G

AA

AG

GG

G

     

Caucasian

264 (0.632)

134 (0.321)

20 (0.048)

0.208

867 (0.707)

321 (0.262)

38 (0.031)

0.162

0.01

1.2 × 10-3

1.36 (1.12 to 1.66)

0.57

0.22

   EP/N

90 (0.383)

104 (0.443)

41 (0.174)

0.396

74 (0.392)

77 (0.407)

38 (0.201)

0.405

0.79

0.17

0.96 (0.73 to 1.27)

0.25

0.03

   EP/Z

25 (0.543)

18 (0.391)

3 (0.065)

0.261

107 (0.704)

39 (0.257)

6 (0.039)

0.168

0.05

0.13

1.75 (1.00 to 3.05)

0.92

0.32

   WP

102 (0.411)

106 (0.427)

40 (0.161)

0.375

63 (0.444)

67 (0.472)

12 (0.085)

0.320

0.13

0.10

1.27 (0.93 to 1.73)

0.16

0.32

   EP/WP

7 (0.467)

6 (0.400)

2 (0.133)

0.333

12 (0.571)

7 (0.333)

2 (0.095)

0.262

0.51

0.38

1.41 (0.51 to 3.92)

0.70

0.53

Combinedc

        

2.0 × 10-3

 

1.25 (1.09 to 1.43)

  
  1. CI, confidence interval; HWE, MAF, OR, odds ratio. aGenotyping success rate: rs1165196 Caucasian, Eastern Polynesian (EP), Western Polynesian (WP) and EP/WP - cases 99.0%, 95.8%, 98.8% and 100%, respectively, controls 99.8%, 96.8%, 96.5% and 90.5%, respectively; rs1183201 Caucasian, EP, WP and EP/WP - cases 97.6%, 95.4%, 96.8% and 100%, respectively, controls 99.7%, 97.1%, 98.6% and 95.2%, respectively; rs9358890 Caucasian, EP, WP and EP/WP - cases 98.3%, 97.5%, 99.6% and 100%, respectively, controls 99.2%, 99.4%, 100% and 90.5%, respectively; rs3799344 Caucasian, EP, WP, EP/WP - cases 96.9%, 96.1%, 98.4% and 100%, respectively, controls 99.8%, 96.0%, 97.2% and 95.2%, respectively; rs12664474 Caucasian, EP, WP, EP/WP - cases 99.3%, 98.9%, 98.8% and 100%, respectively, controls 99.8%, 97.7%, 98.6% and 100%, respectively. bAdjusted for sex. cMeta-analysis by the Mantel-Haenszel method. Breslow-Day test for heterogeneity: rs1165196, P = 0.45; rs1183201, P = 0.75; rs9358890, P = 0.77; rs3799344, P = 0.58; rs12664474, P = 0.97. dPopulation attributable risk (the reduction in gout incidence if the risk variant was absent) for positivity of the risk (T) allele of rs1183201 is 38.2% for Caucasian, 21.4% for EP/N, 27.3% for EP/N and 41.3% for WP.
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Arthritis Research & Therapy

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