Bias in effect size of systemic lupus erythematosus susceptibility loci across Europe: a case-control study

Table 1 Sample collections, proportion of women, frequencies of the three more informative AIMs and North/South score

	DNA sample		Women (%)		AIM frequency (%)			N/S score
Collection^a	Control	SLE	Control	SLE	rs12913832	rs382259	rs6730157
NL	180	104	59.4	86.5	83.0	77.6	72.5	100.0
BE^b	106	147	93.5	90.5
DE	95	90	n.a.	90	77.9	68.1	56.9	80.5
CZ^b	100	101	32	85.1
SK	93	94	93.5	91.5	72.8	63.8	39.4	64.4
HU	95	95	48.4	90.4	63.4	59.6	39.0	54.9
ES, LCG	145	88	82.9	92	35.4	67.4	45.3	47.6
ES, OVD	200	147	69	91.8	30.5	70.4	45.4	47.2
ES, SCQ	95	109	48.4	96	35.1	68.2	41.3	46.0
ES, BCN	97	90	52.6	91.1	32.6	63.2	41.6	40.5
ES, MAD	281	92	68.8	91.3	33.1	61.9	42.3	40.0
PT	97	100	91.3	95.3	28.7	60.7	39.1	34.6
IT, MXP	106	129	42.5	86.8	47.6	49.1	19.8	26.2
IT, ROM	102	84	55.9	89.7	38.2	51.9	15.3	20.3
GR, AUMS	100	95	92	91.6	36.0	44.0	13.4	11.3
IT, NAP	109	79	100	90.1	38.6	42.2	10.0	9.6
GR, EH	100	98	67	86.7	36.7	38.0	13.5	6.8

Collections are in descending order of N/S score. ^aCollections from: University Medical Center Groningen, The Netherlands (NL); Université Catholique de Louvain, Belgium (BE); Hannover Medical School, Germany (DE); Institute of Rheumatology, The Czech Republic (CZ); Martin Faculty Hospital, Slovakia (SK); Albert Szent-Györgyi Medical and Pharmaceutical Centre, Hungary (HU); Complexo Hospitalario Universitario A Coruña, Spain (ES, LCG); Hospital Universitario Central de Asturias, Spain (ES, OVD); Hospital Clinico Universitario de Santiago, Spain (ES, SCQ); Hospital Val d'Hebron of Barcelona, Spain (ES, BCN); Hospital 12 de Octubre, Madrid, Spain (ES, MAD); Hospital Garcia de Orta, Almada, Portugal (PT); University of Milan and Fondazione IRCCS Ospedale Maggiore Policlinico from Milan, Italy (IT, MXP), Ospedale S. Camillo - Forlanini from Roma, Italy (IT, ROM); Athens University Medical School, Athens, Greece (GR, AUMS); Second University of Naples, Italy (IT, NAP); and Evangelismos Hospital, Athens, Greece (GR, EH). ^bThese two collections were not analysed further because of differences in AIM frequencies between cases and controls.

ISSN: 1478-6362