| |
RAF (%)
|
RAF vs. N/S score
|
|---|
|
SNP (locus)
|
Central European
|
Southern European
|
χ2 P value
|
r
xy
|
Slope
|
P value
|
|---|
|
rs3131379 (MSH5)
|
14.9
|
4.6
|
4.9 × 10-26
|
0.92
|
4.15
|
2.0 × 10-6
|
|
rs2187668 (HLA-DQA1)
|
15.7
|
8.7
|
1.9 × 10-9
|
0.88
|
4.93
|
4.0 × 10-5
|
|
rs2476601 (PTPN22)
|
11.8
|
6.1
|
1.5 × 10-8
|
0.74
|
4.21
|
2.7 × 10-3
|
|
rs13277113 (C8orf13-BLK)
|
31.0
|
23.2
|
2.2 × 10-6
|
0.20
|
0.95
|
NS
|
|
rs6445975 (PXK)
|
29.0
|
22.6
|
7.5 × 10-5
|
0.66
|
2.67
|
0.01
|
|
rs1143679 (ITGAM)
|
11.9
|
16.7
|
4.9 × 10-4
|
-0.59
|
-4.79
|
0.03
|
|
rs2205960 (TNFSF4)
|
25.2
|
20.7
|
4.9 × 10-3
|
0.15
|
1.08
|
NS
|
|
rs1801274 (FCGR2A)
|
44.5
|
48.6
|
0.03
|
-0.40
|
-1.25
|
NS
|
|
rs4963128 (KIAA1542)
|
69.1
|
65.3
|
0.03
|
0.58
|
2.83
|
0.03
|
|
rs10488631 (IRF5)
|
11.6
|
9.3
|
0.046
|
0.46
|
3.64
|
0.10
|
|
rs17435 (MECP2)a
|
20.9
|
22.8
|
NS
|
-0.57
|
-2.84
|
0.03
|
|
rs573775 (ATG5)
|
28.2
|
26.3
|
NS
|
0.51
|
4.10
|
0.06
|
|
rs7574865 (STAT4)
|
23.3
|
23.8
|
NS
|
-0.51
|
-4.63
|
0.06
|
|
rs6920220 (TNFAIP3)
|
19.3
|
17.8
|
NS
|
0.49
|
2.74
|
0.07
|
|
rs10798269 (1q25.1)
|
66.2
|
69.0
|
NS
|
-0.17
|
-1.16
|
NS
|
|
rs5754217 (UBE2L3)
|
22.8
|
20.8
|
NS
|
0.16
|
1.28
|
NS
|
|
rs2304256 (TYK2)
|
73.1
|
71.0
|
NS
|
0.06
|
0.23
|
NS
|
|
rs2230926 (TNFAIP3)
|
3.5
|
4.3
|
NS
|
-0.21
|
-3.42
|
NS
|
|
rs729302 (IRF5)
|
67.8
|
69.0
|
NS
|
-0.00
|
-0.03
|
NS
|
|
rs17266594 (BANK1)
|
71.2
|
70.9
|
NS
|
0.32
|
1.99
|
NS
|
- Comparison of the risk allele frequencies (RAFs) between Central and Southern European controls, and linear regression of RAFs to the North/South score (N/S score) of population differentiation (from Table 1). NS, not significant. aAnalysis performed only in women because the locus is in the X chromosome.
