Figure 3

Receiver operating characteristics (ROC) curves for the IRGs as predictor for nonresponse upon RTX treatment in the validation cohort ( n = 26). A. AUC (0.82) for the eight IRG set based on ΔDAS28 response criteria, B. AUC (0.87) for the three IRG set based on ΔDAS28 response criteria, C. AUC (0.78) for the eight IRG set based on EULAR response criteria (responders and intermediate responders vs. non-responders) and D. AUC (0.83) for the three IRG set based on EULAR response criteria (responders and intermediate responders versus non-responders). On the y-axis sensitivity and on the x-axis 1-specificity is indicated. AUC, area under the curve; DAS28, 28 joints disease activity score; EULAR, European League against Rheumatism; IRGs, interferon response genes; RTX, rituximab.