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Table 1 Baseline characteristics of the AS study population

From: The effect of three years of TNF alpha blocking therapy on markers of bone turnover and their predictive value for treatment discontinuation in patients with ankylosing spondylitis: a prospective longitudinal observational cohort study

Number of patients

111

  

Age (yrs)

42.2 ± 10.3

  

Gender (male) (n, %)

78 (70)

  

Duration of symptoms (yrs)

16 (1 to 49)

  

Time since diagnosis (yrs)

9 (0 to 37)

  

HLA-B27+ (n, %)

88 (81)

  

History of IBD (n, %)

11 (10)

  

History of uveitis (n, %)

31 (28)

  

History of psoriasis (n, %)

9 (8)

  

Peripheral arthritis (n, %)

21 (19)

  

Current NSAID use (n, %)

98 (88)

  

Current DMARD use (n, %)

26 (23)

  

BASDAI (range 0 to 10)

6.1 ± 1.7

BASDAI ≥ 4 (n, %)

98 (88)

ASDASCRP

3.8 ± 0.8

ASDASCRP ≥ 2.1 (n, %)

105 (96)

Physician's GDA (range 0 to 10)

5 (1 to 9)

  

Patient's GDA (range 0 to 10)

7 (1 to 10)

  

ESR (mm/h)

22 (2 to 90)

Increased ESR (n, %)

86 (78)

CRP (mg/l)

15 (2 to 99)

Increased CRP (n, %)

84 (76)

BASFI (range 0 to 10)

6.1 ± 2.0

  

Chest expansion (cm)

3.0 (0.5 to 10.0)

  

Modified Schober test (cm)

2.9 (0.1 to 7.0)

  

Occiput to wall distance (cm)

5.0 (0.0 to 28.0)

  

Lateral lumbar flexion L (cm)

8.7 ± 4.1

  

Lateral lumbar flexion R (cm)

8.4 ± 4.3

  

ASQoL (range 0 to 18)

10 ± 4

  

BALP (U/L)

17.2 (1.6 to 36.5)

  

BALP Z-score

0.28 (-2.59 to 5.16)

  

PINP (μg/l)

45.6 (16.0 to 98.0)

  

PINP Z-score

0.35 (-1.75 to 3.63)

  

sCTX (pg/ml)

206.0 (13.4-657.1)

  

sCTX Z-score

-0.34 (-2.58 to 4.01)

  

LS BMD T-score

-0.58 ± 1.41

Osteopenia LS (n, %)

34 (34)

  

Osteoporosis LS (n, %)

9 (9)

LS BMD Z-score

 

LS Z-score ≤ -2.0 (n, %)

9 (9)

Hip BMD T-score

-0.53 ± 1.12

Osteopenia hip (n, %)

38 (37)

  

Osteoporosis hip (n, %)

2 (2)

Hip BMD Z-score

 

Hip Z-score ≤ -2.0 (n, %)

4 (4)

  1. Values are mean ± SD or median (range) unless otherwise indicated.
  2. AS, Ankylosing Spondylitis; ASDAS, Ankylosing Spondylitis Disease Activity Score; BALP, bone-specific-alkaline phosphatase; BASDAI, Bath Ankylosing Spondylitis Disease Activity Index; BASFI, Bath Ankylosing Spondylitis Functional Index; BMD, bone mineral density; CRP, C-reactive protein; DMARD, disease-modifying antirheumatic drug; ESR, erythrocyte sedimentation rate; GDA, global disease activity; HLA-B27+, human leukocyte antigen B27 positive; IBD, inflammatory bowel disease; L, left; LS, lumbar spine;. NSAID, non-steroidal anti-inflammatory drug; PINP, procollagen type 1 N-terminal peptide; R, right; sCTX, serum C-telopeptide of type I collagen