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Table 1 Clinical scores of inflammation and joint erosion in wild-type and peptidyl arginine deiminase 4 knockout K/BxN mice

From: PAD4 is not essential for disease in the K/BxN murine autoantibody-mediated model of arthritis

Group Inflammation (0 to 5)
(mean ± STDEV)
Joint Erosion (0 to 5)
(mean ± STDEV)
WT 3.4 ± 1.3 2.5 ± 1.4
PAD4 KO 3.6 ± 1.0 2.2 ± 1.7
  1. Pathological scoring of immune invasion and joint destruction in wild type (WT) and peptidyl arginine deiminase 4 knockout (PAD4 KO) K/BxN mice. WT (n = 27) and PAD4 KO (n = 29) animals were immunized with pooled K/BxN serum as described, sacrificed at day 10 post injection (p.i.), and their legs prepared for histology. Hematoxylin- and eosin-stained slides were scored blinded by a trained observer for immune cell invasion (0 to 5) and joint erosion (0 to 5). Results are represented as the average of 27 and 29 mice per genotype ± standard deviation. Average scores for joint invasion and erosion were similar in WT and PAD4 KO mice.