Skip to main content

Table 1 Arthritis is exacerbated in IL-4-deficient mice and suppressed in IFN-γ-deficient mice

From: Th1 and Th2 cytokines regulate proteoglycan-specific autoantibody isotypes and arthritis

Mice Incidence (arthritis/total) (%) Arthritis score of diseased micea Day of onsetb
Wild-type 9/12 (75) 5.2 ± 2.5 11.8 ± 6.6
IL-4-/- 9/9 (100) 9.6 ± 1.1* 9.5 ± 6.0
IFN-γ-/- 5/22 (22) 2.4 ± 2.0* 36.8 ± 6.2**
  1. aMean arthritic score for wild-type and IL-4-deficient mice was maximum at day 23 and for the IFN-γ-deficient mice at day 41 after the last immunization with PG. bDays from last immunization with PG to onset of disease. *Score differed significantly from that for wild-type mice (P < 0.05). **Time to onset of disease differed significantly from that in wild-type mice (P < 0.002).