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Table 1 Arthritis is exacerbated in IL-4-deficient mice and suppressed in IFN-γ-deficient mice

From: Th1 and Th2 cytokines regulate proteoglycan-specific autoantibody isotypes and arthritis

Mice

Incidence (arthritis/total) (%)

Arthritis score of diseased micea

Day of onsetb

Wild-type

9/12 (75)

5.2 ± 2.5

11.8 ± 6.6

IL-4-/-

9/9 (100)

9.6 ± 1.1*

9.5 ± 6.0

IFN-γ-/-

5/22 (22)

2.4 ± 2.0*

36.8 ± 6.2**

  1. aMean arthritic score for wild-type and IL-4-deficient mice was maximum at day 23 and for the IFN-γ-deficient mice at day 41 after the last immunization with PG. bDays from last immunization with PG to onset of disease. *Score differed significantly from that for wild-type mice (P < 0.05). **Time to onset of disease differed significantly from that in wild-type mice (P < 0.002).