TY - JOUR AU - Hiyama, Akihiko AU - Arai, Fumiyuki AU - Sakai, Daisuke AU - Yokoyama, Katsuya AU - Mochida, Joji PY - 2012 DA - 2012/05/02 TI - The effects of oxygen tension and antiaging factor Klothoon Wnt signaling in nucleus pulposus cells JO - Arthritis Research & Therapy SP - R105 VL - 14 IS - 3 AB - The goals of this study were to examine the oxemic regulation of Wnt signaling to explore whether Wnt signaling accelerates the age-related degeneration of nucleus pulposus cells, and if so, to define the mechanism underlying this effect. We investigated the expression of Klotho, a newly identified antiaging gene, and whether its regulation is attributable to the suppression of Wnt signaling. SN - 1478-6354 UR - https://doi.org/10.1186/ar3830 DO - 10.1186/ar3830 ID - Hiyama2012 ER -