TY - JOUR AU - Dejica, Valeria M. AU - Mort, John S. AU - Laverty, Sheila AU - Antoniou, John AU - Zukor, David J. AU - Tanzer, Michael AU - Poole, A. Robin PY - 2012 DA - 2012/05/14 TI - Increased type II collagen cleavage by cathepsin K and collagenase activities with aging and osteoarthritis in human articular cartilage JO - Arthritis Research & Therapy SP - R113 VL - 14 IS - 3 AB - The intra-helical cleavage of type II collagen by proteases, including collagenases and cathepsin K, is increased with aging and osteoarthritis (OA) in cartilage as determined by immunochemical assays. The distinct sites of collagen cleavage generated by collagenases and cathepsin K in healthy and OA human femoral condylar cartilages were identified and compared. SN - 1478-6354 UR - https://doi.org/10.1186/ar3839 DO - 10.1186/ar3839 ID - Dejica2012 ER -