HDL2-chol and HDL3-chol concentrations in a group of RA patients with low, moderate and high disease activity levels. HDL2-chol and HDL3-chol concentrations were similar across all categories of the DAS28 (low <3.2; n = 31, medium 3.2 to 5.1; n = 6, and high >5.1; n = 8). The results of the regression analysis showed a small effect of DAS28 on HDL2-chol; a decrease in HDL2-chol of 0.06 mmol/L with every point increase in DAS28 (P = 0.05). Disease activity did not significantly relate to HDL3-chol, which decreased by 0.02 mmol/L with every point increase in DAS28 (P = 0.19). DAS28, disease activity score (28 joints); HDL, high density lipoprotein; n, number; RA, rheumatoid arthritis.