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Table 4 Linear and binary regression between classical CVD risk and endothelial function in RA patients from the cross-sectional study

From: The role of inflammation and cardiovascular disease risk on microvascular and macrovascular endothelial function in patients with rheumatoid arthritis: a cross-sectional and longitudinal study

 

Microvascular function

Macrovascular function

 

Endothelium-dependent

Endothelium- independent

Endothelium- dependent

Endothelium- independent

CVD risk factors

    

   Insulin

β = 0.13, P = 0.23

β = 0.04, P = 0.73

β = -0.04, P = 0.71

β = -0.25, R2 = 0.065a

   HOMA

β = 0.09, P = 0.41

β = -0.01, P = 0.95

β = -0.06, P = 0.61

β = -0.23, R2 = 0.052a

QUICKI

β = -0.07, P = 0.53

β = -0.02, P = 0.88

β = 0.11, P = 0.30

β = 0.30, R2 = 0.095b

   High cholesterol

OR = 1.01 (0.99-1.00)

OR = 1.00 (0.99-1.00)

OR = 1.08 (0.99-1.17)

OR = 1.09 (1.02-1.17)a

   Hypertension

OR = 1.00 (1.00-1.00)

OR = 1.00 (0.99-1.00)

OR = 1.08 (0.99-1.17)

OR = 1.07 (1.01-1.14)a

   Cigarette smoking

OR = 1.00 (1.00-1.00)

OR = 1.00 (1.00-1.00)

OR = 1.04 (0.97-1.13)

OR = 1.04 (0.99-1.10)

Global CVD risk

    

   FRS

β = -0.26, R2 = 0.068b

β = -0.18, P = 0.09

β = -0.12, P = 0.26

β = -0.32, R2 = 0.101b

   TC score

β = -0.28, R2 = 0.077a

β = -0.17, P = 0.18

β = -0.23, P = 0.08

β = -0.14, P = 0.30

   TC/HDL score

β = -0.26, R2 = 0.068a

β = -0.17, P = 0.19

β = -0.25, P = 0.05

β = -0.17, P = 0.18

   Reynolds Risk Score

β = -0.30, R2 = 0.088a

β = -0.12, P = 0.37

β = -0.27, R2 = 0.072a

β = -0.51, R2 = 0.259b

   QRISK 2

β = -0.33, R2 = 0.109b

β = -0.19, P = 0.08

β = -0.22, R2 = 0.048a

β = -0.51, R2 = 0.255b

  1. CVD risk factors and global CVD risk scores were entered as independent variables, and endothelial functions, as dependent variables in the linear and binary regression analysis. Odds ratio (OR) with 95% confidence interval is presented for all binary regression analysis. CVD, cardiovascular disease; FRS, Framingham risk score; HDL, high-density lipoprotein; HOMA, homeostasis model assessment; QUICKI, quantitative insulin sensitivity check index; SCORE, systematic coronary risk evaluation; TC, total cholesterol. aP < 0.05; bP < 0.01. R2 value is shown for all significant associations only.