# Table 4 Linear and binary regression between classical CVD risk and endothelial function in RA patients from the cross-sectional study

Microvascular function Macrovascular function
Endothelium-dependent Endothelium- independent Endothelium- dependent Endothelium- independent
CVD risk factors
Insulin β = 0.13, P = 0.23 β = 0.04, P = 0.73 β = -0.04, P = 0.71 β = -0.25, R2 = 0.065a
HOMA β = 0.09, P = 0.41 β = -0.01, P = 0.95 β = -0.06, P = 0.61 β = -0.23, R2 = 0.052a
QUICKI β = -0.07, P = 0.53 β = -0.02, P = 0.88 β = 0.11, P = 0.30 β = 0.30, R2 = 0.095b
High cholesterol OR = 1.01 (0.99-1.00) OR = 1.00 (0.99-1.00) OR = 1.08 (0.99-1.17) OR = 1.09 (1.02-1.17)a
Hypertension OR = 1.00 (1.00-1.00) OR = 1.00 (0.99-1.00) OR = 1.08 (0.99-1.17) OR = 1.07 (1.01-1.14)a
Cigarette smoking OR = 1.00 (1.00-1.00) OR = 1.00 (1.00-1.00) OR = 1.04 (0.97-1.13) OR = 1.04 (0.99-1.10)
Global CVD risk
FRS β = -0.26, R2 = 0.068b β = -0.18, P = 0.09 β = -0.12, P = 0.26 β = -0.32, R2 = 0.101b
TC score β = -0.28, R2 = 0.077a β = -0.17, P = 0.18 β = -0.23, P = 0.08 β = -0.14, P = 0.30
TC/HDL score β = -0.26, R2 = 0.068a β = -0.17, P = 0.19 β = -0.25, P = 0.05 β = -0.17, P = 0.18
Reynolds Risk Score β = -0.30, R2 = 0.088a β = -0.12, P = 0.37 β = -0.27, R2 = 0.072a β = -0.51, R2 = 0.259b
QRISK 2 β = -0.33, R2 = 0.109b β = -0.19, P = 0.08 β = -0.22, R2 = 0.048a β = -0.51, R2 = 0.255b
1. CVD risk factors and global CVD risk scores were entered as independent variables, and endothelial functions, as dependent variables in the linear and binary regression analysis. Odds ratio (OR) with 95% confidence interval is presented for all binary regression analysis. CVD, cardiovascular disease; FRS, Framingham risk score; HDL, high-density lipoprotein; HOMA, homeostasis model assessment; QUICKI, quantitative insulin sensitivity check index; SCORE, systematic coronary risk evaluation; TC, total cholesterol. aP < 0.05; bP < 0.01. R2 value is shown for all significant associations only.