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Figure 4 | Arthritis Research & Therapy

Figure 4

From: Cytokine-stimulated T cells induce macrophage IL-10 production dependent on phosphatidylinositol 3-kinase and p70S6K: implications for rheumatoid arthritis

Figure 4

Induction of macrophage IL-10 production by T cells from synovial membranes in rheumatoid arthritis (RA-Ts) is PI3K- and p70S6K-dependent. RA-Ts were co-cultured with M-CSF-primed macrophages in the presence or absence of the PI3K inhibitor wortmannin (50 nM) or the p70S6K inhibitor rapamycin (1 nM). Bars show mean IL-10 in triplicate culture supernatants ± SD, for a representative of N = 3 replicate experiments. p70S6K = p70 S6-kinase; PI3K = phosphatidylinositol 3-kinase; Rapa = rapamycin; T:M = ratio of RA-Ts:macrophages; Wort = wortmannin. *P < 0.05, **P < 0.01.

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